The Effects of Sex Hormones on Cognition and Mood in Older Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Completion Date

2005-06-30

Brief Summary

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This study is investigating the effects of hormone replacement therapy on memory, mental abilities and mood in older adults aged 65-90. During the nine month long study, men will take testosterone for three months and women will take estrogen for three months. At four points during the study (once every three months), participants will complete a test battery and have blood drawn.

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Detailed Description

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Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only).

Conditions

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Cognition Disorders Mood Disorders

Study Design

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Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Estrogen

Intervention Type DRUG

Testosterone

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Women and men aged 65-90 who have not received hormone replacement for the last three months.

Exclusion Criteria

* Previous head injury with loss of consciousness for more than one hour.
* Men with a history of prostate cancer.
* Men on testosterone replacement within the past three months.
* Women with a history of breast or uterine cancer.
* Women on estrogen replacement within the past three months.

Minimum Eligible Age

65 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes