CARE-ID: Dynamics of Respiratory Infections in Children and Transmission in Households and Schools

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-10-10

Study Completion Date

2026-12-31

Brief Summary

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Viral respiratory tract infections are very common in children. They contribute to missed time in school, work disruption for caregivers and can also cause severe illness requiring hospitalization and rarely death. In the 2022-2023, influenza, RSV and SARS-CoV-2 viruses infected a large number of children which strained the pediatric healthcare system in many jurisdictions. Unfortunately, there continues to be limited data on duration of infectiousness and transmission risk of these viruses to inform public health decisions during times when there is significant circulation of these viruses.

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Detailed Description

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Conditions

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SARS CoV 2 Infection RSV Infection Influenza Mycoplasma Pneumoniae Bordetella Pertussis, Whooping Cough

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Daily Influenza, RSV or SARS-CoV-2 PCR testing for 14 days

Each participant will undergo daily PCR testing for Influenza, RSV or SARS-CoV-2 to assess viral dynamics

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

Viral dynamics (primary outcome):

* The child must be less than 18 years of age
* Have a positive PCR sample for influenza, RSV or SARS-CoV-2,
* Have any one of the symptoms listed to meet testing eligibility: fever, cough, shortness of breath, decreased or loss of taste or smell, muscle aches/joint pains (unusual, long lasting, not related to injury), extreme tiredness (unusual fatigue not otherwise explained), sore throat, runny or stuffy/congested nose, headache (new, unusual, long-lasting), nausea/vomiting and/or diarrhea, and
* Be within 5 days of symptom onset

-Any individual in the same household (i.e. household contacts, defined as residing at the same address) as the individual testing positive by PCR for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, or bordetella pertussis

-Any individual in the same classroom (i.e. classroom contacts) as the individual testing positive by PCR for influenza, RSV, SARS-CoV-2, mycoplasma pneumoniae, or bordetella pertussis (i.e. case identified through the THS program)