Impact of the Covid-19 on Respiratory Syncytial Virus (RSV) Epidemic

NCT ID: NCT04944160

Last Updated: 2022-05-02

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 600 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-03-15
• Study Completion Date: 2021-06-28

Brief Summary

The magnitude of seasonal Respiratory Syncytial Virus (RSV) epidemics brings each year new logistical challenges for the hospitalization of young infants with bronchiolitis that overwhelm hospital capacities and lead to specific winter plans with deprogramming and mobilization of human and logistical resources. The Covid-19 pandemic has changed the way winter epidemics are presented. For example, the seasonal RSV epidemic was shifted by several months in Lyon, with an impression of a lower incidence of hospitalized cases, with a population of older children and with fewer signs of clinical severity. This is largely attributable to the widespread use of barrier gestures and social distancing measures, known as "Non-Pharmacological Interventions" (NPI). Given the magnitude of the reduction of the RSV epidemic, it is legitimate to analyze the benefits of NPIs to draw lessons for maintaining preventive measures around RSV-vulnerable populations; moreover, new preventive pharmacological interventions are soon to be marketed, whether they are particularly refined and long half-life anti-RSV monoclonal antibodies, RSV vaccines for mothers or for newborns and infants. In this perspective, it is crucial to properly define the populations at risk of severe disease to establish a legitimate hierarchy in the implementation of different preventive strategies. The study of the RSV epidemic is a high potential model because of the convergence of epidemiological, virological, and pharmacological knowledge. However, the study of the impact of the pandemic on the epidemiology of rhinovirus also seems promising because, for reasons unknown to date, it seems that the pandemic did not have the same reducing impact on the rhinovirus epidemic; in the latter case, the interest is to confirm the resistance of this virus and to look for more fundamental explanations, for example, on viral interactions.

Conditions

RSV Infection

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Pre Covid-19 cohort

Children hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a reverse transcriptase - polymerase chain reaction (RT-PCR) positive for Respiratory Syncytial Virus (RSV) during the 2019-2020 winter epidemic

Medical records analysis

Intervention Type: OTHER

To review of medical records to describe diagnosis and severity of the disease.

Comparison of cohorts

Intervention Type: OTHER

To compare pre and post Covid-19 epidemics in terms of numbers of admissions, and proportion of severe disease.

Post Covid-19 cohort

Children hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a reverse transcriptase - polymerase chain reaction (RT-PCR) positive for Respiratory Syncytial Virus (RSV) during the 2020-2021 winter epidemic

Medical records analysis

Intervention Type: OTHER

To review of medical records to describe diagnosis and severity of the disease.

Comparison of cohorts

Intervention Type: OTHER

To compare pre and post Covid-19 epidemics in terms of numbers of admissions, and proportion of severe disease.

Interventions

Medical records analysis

To review of medical records to describe diagnosis and severity of the disease.

Intervention Type: OTHER

Comparison of cohorts

To compare pre and post Covid-19 epidemics in terms of numbers of admissions, and proportion of severe disease.

Intervention Type: OTHER

Other Intervention Names

Epidemiology

Eligibility Criteria

Inclusion Criteria

• • Child hospitalized at " Hôpital Femme Mère Enfant ", Lyon, France

• Polymerase Chain Reaction (PCR) positive at Respiratory Syncytial Virus (RSV)

Exclusion Criteria

• • Parent's refusal to participate

• Maximum Eligible Age: 5 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hospices Civils de Lyon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Groupement Hospitalier EST - Hospices Civils de Lyon

Bron, , France

Countries

France

References

Casalegno JS, Ploin D, Cantais A, Masson E, Bard E, Valette M, Fanget R, Targe SC, Myar-Dury AF, Doret-Dion M, Massoud M, Queromes G, Vanhems P, Claris O, Butin M, Pillet S, Ader F, Bin S, Gaymard A, Lina B, Morfin F; VRS study group in Lyon; Javouhey E, Gillet Y. Characteristics of the delayed respiratory syncytial virus epidemic, 2020/2021, Rhone Loire, France. Euro Surveill. 2021 Jul;26(29):2100630. doi: 10.2807/1560-7917.ES.2021.26.29.2100630.

Reference Type: DERIVED

PMID: 34296674 (View on PubMed)

Other Identifiers

502

Identifier Type: -

Identifier Source: org_study_id