Severity of RSV Infections in Twins

NCT ID: NCT05070975

Last Updated: 2022-07-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 94 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-11-05
• Study Completion Date: 2022-01-27

Brief Summary

Respiratory syncytial virus (RSV) infection is the most common cause of severe lower respiratory tract infection (LRTI) in the pediatric population worldwide. Age at the time of infection, prematurity, multiparity, exposure to smoke and the level of passive immunity transmitted at birth are the main risk factors for lower respiratory infection associated with RSV. Other factors, including the innate immune response, respiratory microbiota, and intra-host viral heterogeneity, may also affect outcomes but are not fully considered in RSV infection. Exploring the impact of these factors is difficult due to the heterogeneity of the population which makes statistical adjustment difficult. Thus, twin models are useful in understanding the impact of the host on the environment, as twins often share similar exposure to infection and many risk factors, but not all are ie different prenatal and postnatal conditions, differential transfer of maternal antibodies and the genetic makeup of heterozygotes.

Conditions

RSV Infection; Bronchiolitis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Twins

Twins identified from the birth cohort (Hospices Civils de Lyon) with at least one twin hospitalized for an acute RSV-infection

Epidemiology

Intervention Type: OTHER

Assessment of the discrepancy of clinical severity of RSV-infections between twin infants.

Interventions

Epidemiology

Assessment of the discrepancy of clinical severity of RSV-infections between twin infants.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Twins born at Hospices Civils de Lyon in the years 2012 to 2020
• At least one twin hospitalized with positive RSV-PCR during the first year of life

Exclusion Criteria

• Major differential underlying disease between twins
• Death of a twin before the RSV epidemic period of the first year of life
• Nosocomial infection
• Lack of understanding of the study or questionnaire by parents
• Lack of parental consent

• Maximum Eligible Age: 354 Days
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hospices Civils de Lyon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Hôpital Femme-Mère-Enfant des Hospices Civils de Lyon

Bron, , France

Countries

France

Other Identifiers

69HCL21_0634

Identifier Type: -

Identifier Source: org_study_id