Impact of the Covid-19 on RSV Epidemic in the Metropolis of Lyon

NCT ID: NCT05348655

Last Updated: 2022-04-27

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 600 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-06-30
• Study Completion Date: 2025-07-31

Brief Summary

The magnitude of seasonal RSV epidemics brings each year new logistical challenges for the hospitalization of young infants with bronchiolitis that overwhelm hospital capacities and lead to specific winter plans with deprogramming and mobilization of human and logistical resources. The Covid-19 pandemic has changed the way winter epidemics are presented. For example, the seasonal RSV epidemic was shifted by several months in Lyon, with an impression of a lower incidence of hospitalized cases, with a population of older children and with fewer signs of clinical severity. This is largely attributable to the widespread use of barrier gestures and social distancing measures, known as "non-pharmacological interventions" or NPI. Given the magnitude of the reduction of the RSV epidemic, it is legitimate to analyze the benefits of NPIs to draw lessons for maintaining preventive measures around RSV-vulnerable populations; moreover, new preventive pharmacological interventions are soon to be marketed, whether they are particularly refined and long half-life anti-RSV monoclonal antibodies, RSV vaccines for mothers or for newborns and infants. In this perspective, it is crucial to properly define the populations at risk of severe disease to establish a legitimate hierarchy in the implementation of different preventive strategies. The study of the RSV epidemic is a high potential model because of the convergence of epidemiological, virological, and pharmacological knowledge. However, the study of the impact of the pandemic on the epidemiology of rhinovirus also seems promising because, for reasons unknown to date, it seems that the pandemic did not have the same reducing impact on the rhinovirus epidemic; in the latter case, the interest is to confirm the resistance of this virus and to look for more fundamental explanations, for example, on viral interactions.

On a previous study (see NTC 04944160), 519 infants were recruited in the Pre-Covid-19 season population, and 277 infants were recruited in the first Per-Covid-19 season population.

Conditions

Rhinovirus; RSV Infection in Children Less Than 5 Years of Age

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Pre Covid-19 cohort

Children hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a RT-PCR positive for RSV during the 2019-2020 winter epidemic

epidemiology

Intervention Type: OTHER

To review of medical records to describe diagnosis and severity of the disease

epidemiology

Intervention Type: OTHER

To compare pre- and per-Covid-19 epidemics in terms of numbers of admissions, and proportion of severe disease.

Per Covid-19 cohort

Children hospitalized in the Pediatric Department of the " Hôpital Femme Mère Enfant ", Lyon, France with a RT-PCR positive for RSV during the 2020-2021, 2021-2022, 2022-2023, and 2023-2024 epidemic. The need for continuation of the study will be reassessed after each season

epidemiology

Intervention Type: OTHER

To review of medical records to describe diagnosis and severity of the disease

epidemiology

Intervention Type: OTHER

To compare pre- and per-Covid-19 epidemics in terms of numbers of admissions, and proportion of severe disease.

Interventions

epidemiology

To review of medical records to describe diagnosis and severity of the disease

Intervention Type: OTHER

epidemiology

To compare pre- and per-Covid-19 epidemics in terms of numbers of admissions, and proportion of severe disease.

Intervention Type: OTHER

Other Intervention Names

Medical records analysis; Comparison of cohorts

Eligibility Criteria

Inclusion Criteria

• Child hospitalized at " Hôpital Femme Mère Enfant ", Lyon, France
• Positive RSV-PCR

Exclusion Criteria

• Parent's refusal to participate

• Maximum Eligible Age: 5 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hospices Civils de Lyon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Virology Lab

Lyon, , France

Pediatric Departement

Lyon, , France

Countries

France

Central Contacts

Dominique PLOIN, PhD

Role: CONTACT

dominique.ploin@chu-lyon.fr

04 27 85 56 42

Jean-Sébastien CASALEGNO, MCU-PH

Role: CONTACT

jean-sebastien.casalegno@chu-lyon.fr

04 72 07 10 23

Other Identifiers

502_3

Identifier Type: -

Identifier Source: org_study_id