Viral Dynamics of Omicron in Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

107 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-02-04

Study Completion Date

2022-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

SARS-CoV-2 transmission is dependent on multiple factors, which may be related to either host-virus interaction or the environment. While there have been several studies evaluation viral dynamics and transmission risk in adults, there is limited pediatric data available. The objective of this study is to characterize the period of communicability for children less than 19 years of age with SARS-CoV-2 infection with the Omicron variant.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

CARE-ID: Dynamics of Respiratory Infections in Children and Transmission in Households and Schools

NCT06640387

SARS CoV 2 Infection RSV Infection Influenza +2 more

RECRUITING

Asymptomatic SARS-CoV-2 Detection in Children

NCT04853316

Covid19 SARS-CoV-2

COMPLETED

Symptom Spectrum and Risk Factors for Fever in Pediatric and Adult Patients With Omicron Infection

NCT06463821

Symptom Spectrum and Risk Factors for Fever

COMPLETED

COVID Infection in Pediatric Surgical Patient

NCT05898529

COVID-19

RECRUITING

The CHILD Cohort COVID-19 Add-On Study

NCT05234359

SARS-CoV Infection Covid19

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The goal of our study is to assess the viral dynamics of SARS-CoV-2 infection in children \< 19 years with acute infection to inform public health practice.

Specific Aims:

1. Describe the kinetics of SARS-CoV-2 viral load in children with acute SARS-CoV-2 infection
2. Assess the impact of various host factors on viral dynamics, including age (\<1 year, 1-4 years, 5-11 years, 12-18 years), symptoms, clinical severity (hospitalization vs. outpatient), comorbidities (immunocompromised vs. not immunocompromised), vaccination (none, 1 dose, 2 doses)
3. Estimate the time point at which children are less likely to be infectious
4. Assess the sensitivity of self-collected rapid antigen testing (RAT) in children, compared to PCR (e.g. assess RAT test performance in children)

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

SARS-CoV2 Infection, COVID-19

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Daily SARS-CoV-2 PCR Testing for 10 days

Each participant will undergo daily SARS-CoV-2 PCR testing to assess viral dynamics

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

To be included in the study, the participant must be:

1. Less than 19 years of age
2. Have a positive molecular or rapid antigen test in the previous 48 hours
3. If symptomatic, onset of any COVID-19 symptom within last 72 hours.
4. If asymptomatic, evidence to support acute infection (e.g. negative PCR in the last 5 days, known household exposure where index case is clear)
5. Able to collect daily samples

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No