Effect of Inhalational Anesthesia Versus Total Intravenous Anesthesia on Blood Glucose in Type 2 Diabetes Patients
NCT ID: NCT06613893
Last Updated: 2025-05-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
84 participants
INTERVENTIONAL
2024-01-01
2025-06-30
Brief Summary
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Detailed Description
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* Study Settings: Ain Shams University hospitals, Cairo, Egypt.
* Study period: 12 months starting from janurary 2024 .
* Study Population: All adult type 2 diabetic patients (30-70 year old) with class II,III based on the American Society of Anesthesiologists (ASA) physical status undergoing elective thoracic surgeries will be randomly assigned into one of the following groups using computer generated codes and opaque sealed envelopes:
1. Group A will receive total inravenous anesthesia (TIVA).
2. Group B will receive inhalational anesthesia (IHA)
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
QUADRUPLE
Study Groups
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Group A will receive total inravenous anesthesia (TIVA)
patients in this group will receive total intravenous anesthesia using propofol infusion after induction of anesthesia, tested variables will be measured according to the protocol
No interventions assigned to this group
Group B will receive inhalational anesthesia (IHA)
patients in this group will receive inhalational anesthesia using isoflurane, tested variables will be measured according to the protocol
Inhalational anesthesia
Anesthesia will be maintained with inhaled isoflurane, Iso-MAC from (0.7 to 1.4%)(Hawkley, Preston, and Maani 2018) and fentanyl infusion (1-2mcg /kg/hour) that will be stopped 30 min before the end of the operation ,The heart rate and blood pressure will be maintained within the range of ±20% of the baseline
Interventions
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TIVA
Anesthesia will be maintained by total intravenous anesthesia with propofol infusion (4 to 12 mcg/kg/min) and fentanyl infusion (1-2mcg /kg/hour) that will be stopped 30 min before the end of the operation ,The heart rate and blood pressure will be maintained within the range of ±20% of the baseline
Inhalational anesthesia
Anesthesia will be maintained with inhaled isoflurane, Iso-MAC from (0.7 to 1.4%)(Hawkley, Preston, and Maani 2018) and fentanyl infusion (1-2mcg /kg/hour) that will be stopped 30 min before the end of the operation ,The heart rate and blood pressure will be maintained within the range of ±20% of the baseline
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Sex: Both sexes
* Patients with type 2 diabetes mellitus controlled with oral hypoglycemic drugs
* Patients with ASA classification II,III
* Duration of surgery (≥2 h)
Exclusion Criteria
* ASA classification Ⅳ to V
* Severe systemic diseases
* Metabolic disorders, diabetic ketoacidosis or hyperglycemia (fasting blood Glucose more than 140 mg/dl)
* Hepatic and/or renal dysfunction
* Neuromuscular disease
* Pancreatic cancer
* History of malignant hyperthermia
* Emergency surgery
* Ischemic heart disease and valvular heart disease
* Body mass index more than 40
* Diabetic patients on insulin therapy
30 Years
70 Years
ALL
No
Sponsors
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Ain Shams University
OTHER
Responsible Party
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Yasser Alaa Abdalmonim
Principal Investigator
Principal Investigators
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Nabila M Abdelaziz, professor
Role: STUDY_DIRECTOR
Ain Shams University
Locations
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Ain Shams University
Cairo, , Egypt
Countries
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Other Identifiers
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FMASU@MD331/2023
Identifier Type: -
Identifier Source: org_study_id
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