Reversal of Neuromuscular Blockade in Diabetic Patients
NCT ID: NCT02057861
Last Updated: 2014-02-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
45 participants
OBSERVATIONAL
2013-01-31
2013-12-31
Brief Summary
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Detailed Description
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Methods: Included patients were divided into 2 groups: diabetic (n=21) and non-diabetic (n=20). All patients were premedicated. After arrival in the operating room, all patients were monitorised with Datex Ohmeda S/5 Anesthesia Machine and electrocardiography (DII derivation), hemodynamic variables, respiratory rate, and inspiratory sevoflurane concentrations were recorded. Neuromuscular monitoring system was used. Anesthesia was induced with propofol 2 mg/kg and fentanyl 1 mcg/kg. After the loss of eyelid reflex the neuromuscular monitoring system automatically identified supramaximal stimulating currents and after that rocuronium 0,6 mg/kg was given. Train of four (TOF) stimulation with the supramaximal current were applied and by recording of second TOF value (TOF2) the patient was intubated. Anesthesia was maintained with 50% O2 + 50% air and sevoflurane of 1-2 % concentration. TOF stimulation was applied and recorded every 20 seconds. Intraoperatively by return T2 rocuronium 0,15 mg/kg was given. T2i time was recorded as intubation time and T2d time was recorded as clinical effect time. At the end of the operation sugammadex 2 mg/kg was given. When TOF rate reached 0,9 patients were extubated and the time was recorded.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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non-diabetic
non-diabetic group; 2 mg/kg sugammadex iv, postoperatively Extubation times were recorded.
No interventions assigned to this group
diabetic
Diabetic group; 2 mg/kg sugammadex iv, postoperatively Extubation times were recorded
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* For diabetic group patients with Diabetes mellitus Type 2 over 10 years.
* For non-diabetic group patients without any glucose metabolism disease
Exclusion Criteria
* diabetic neuropathy and nephropathy
* hepatic, renal and cardiac diseases
18 Years
65 Years
ALL
No
Sponsors
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Duzce University
OTHER
Responsible Party
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yavuz demiraran
Professor Doctor
Principal Investigators
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yavuz demiraran, professor
Role: PRINCIPAL_INVESTIGATOR
Duzce University
Locations
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Duzce University
Düzce, , Turkey (Türkiye)
Countries
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Other Identifiers
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ozlemersoy
Identifier Type: -
Identifier Source: org_study_id
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