Xenograft with or Without Erythropoietin in Immediate Dental Implant

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-14

Study Completion Date

2026-01-31

Brief Summary

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The aim of this study is to evaluate changes in buccal bone thickness after immediate implant placement with xenograft mixed with erythropoietin in the anterior maxilla with a thin buccal bone

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Detailed Description

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PICO:

Population: Patients with non-restorable tooth in anterior maxilla with thin buccal bone (less than 1mm) Intervention: Immediate implant placement with Xenograft mixed with Erythropoietin.

Control: Immediate implant placement with Xenograft alone.

Conditions

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Hopeless Teeth

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Group A (Test)

Immediate implant placement with Xenograft mixed with Erythropoietin

Group Type EXPERIMENTAL

Erythropoietin (EPO) with xenograft

Intervention Type COMBINATION_PRODUCT

After atraumatic extraction of the non-restorable tooth, Implant will be placed palatal and apical to osteotomy with at least 2mm gap junction between implant and buccal bone which will be grafted with xenograft and erythropoietin.

Group B (Control)

Immediate implant placement with Xenograft alone

Group Type ACTIVE_COMPARATOR

Xenograft alone

Intervention Type OTHER

After atraumatic extraction of the non-restorable tooth, implant will be placed palatal and apical to osteotomy with at least 2mm gap junction between implant and buccal bone which will be grafted with xenograft alone.

Interventions

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Erythropoietin (EPO) with xenograft

After atraumatic extraction of the non-restorable tooth, Implant will be placed palatal and apical to osteotomy with at least 2mm gap junction between implant and buccal bone which will be grafted with xenograft and erythropoietin.

Intervention Type COMBINATION_PRODUCT

Xenograft alone

After atraumatic extraction of the non-restorable tooth, implant will be placed palatal and apical to osteotomy with at least 2mm gap junction between implant and buccal bone which will be grafted with xenograft alone.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult (≥18 years) with non-restorable maxillary teeth in the esthetic zone (upper right second premolar to upper left second premolar).
* Intact with thin labial plate of bone (≤1mm).
* The recipient site of the implant should be free from any pathological conditions.
* Patients who are cooperative, motivated and hygiene conscious.
* Appropriate crown height space to maintain favorable crown : implant ratio

Exclusion Criteria

* Systemic conditions/diseases that contraindicate surgery.
* Patients who have any habits that might jeopardize the osseointegration process, such as current smokers.
* Patients with parafunctional habits that produce overload on implant, such as bruxism and clenching.
* Patients with periodontal disease.
* Alcohol or drug abuse.
* Pregnant and lactating women.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No