Evaluation of Marginal Bone Loss After Immediate Implant Placement in Maxillary Esthetic Zone With Nanobone Versus Xenograft

NCT ID: NCT03536260

Last Updated: 2018-05-24

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-07-01
• Study Completion Date: 2018-06-30

Brief Summary

Immediate implant placement has a success rate from 94-100 % . After tooth extraction there is a loss in the horizontal and vertical dimension by about 3-6 mm and 1-2 mm respectively and alveolar crest resorption of about 44% especially through 6 months after extraction.

After immediate implant placement there is usually a void between the implant and the socket walls which is called jumping distance or gap which may heal spontaneously or need bone graft to bridge the space. If the gap is 1-2 mm it may heal spontaneously more than that this will need bone graft. There is no evidence that the graft impairs osseointegration Development of artificial bone has increasingly progressed in the last few years. Nanobone "nanocrystalline hydroxyapatite embedded in a porous silica gel matrix bone graft is introduced which has osseoconductive and biomimetic properties .the sub-micron modification in the bone substitute will enhance osteogenic property. It bind to the bone by stimulation of osteoblast activity and enhance growth factors which improve bone healing and provide more strength and stability to the implant.

Conditions

Implant Placement in Maxillary Esthetic Zone

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: QUADRUPLE

Study Groups

Immediate implant with Xenograft

Group Type: ACTIVE_COMPARATOR

Implant with Xenograft

Intervention Type: DEVICE

Using of Xenograft to fill the gap in the socket after immediate implant placement

Immediate implant with Nanobone

Group Type: ACTIVE_COMPARATOR

Implant with NanoBone graft

Intervention Type: DEVICE

Using of NanoBone graft to fill the gap in the socket after immediate implant placement

Interventions

Implant with NanoBone graft

Using of NanoBone graft to fill the gap in the socket after immediate implant placement

Intervention Type: DEVICE

Implant with Xenograft

Using of Xenograft to fill the gap in the socket after immediate implant placement

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Adult patients with badly broken teeth in upper esthetic zone indicated for extraction, presence of at least 4 mm of bone beyond the root apex to guarantee implant primary stability, implant placement within the alveoli confines.
• Both sexes.
• No intraoral soft and hard tissue pathology.
• No systemic condition that contraindicate implant placement.

Exclusion Criteria

• Presence of fenestrations or dehiscence of the residual bony Walls after extraction.
• Heavy smokers more than 20 cigarettes per day .(24)
• Patients with systemic disease that may affect normal healing.
• Psychiatric problems
• Disorders to implant are related to history of radiation therapy to the head and neck neoplasia, or bone augmentation to implant site

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Abdullah Mohammed Farahat

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Faculty of Dentistry , Cairo university

Cairo, , Egypt

Countries

Egypt

Other Identifiers

FarahatMBL

Identifier Type: -

Identifier Source: org_study_id