Clinical Study of Intestinal Barrier Dysfunction After Gastrointestinal Surgery

NCT ID: NCT06596070

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

180 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-10-31

Study Completion Date

2025-04-30

Brief Summary

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The goal of this observational study is to explore the clinical influences associated with the development of intestinal barrier dysfunction in patients undergoing gastrointestinal surgery. The main question it aims to answer is:What clinical factors increase the probability of developing intestinal barrier dysfunction in patients after gastrointestinal surgery?

Detailed Description

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Conditions

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Intestinal Barrier Dysfunction

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Intestinal barrier dysfunction group

No intervention was carried out

Intervention Type OTHER

This study is an observational study and no intervention was performed on the patients.

Non-intestinal barrier dysfunction group

No intervention was carried out

Intervention Type OTHER

This study is an observational study and no intervention was performed on the patients.

Interventions

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No intervention was carried out

This study is an observational study and no intervention was performed on the patients.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* men or women aged 18-80 years
* expected feasible abdominal surgical treatment (partial gastrectomy, colorectal resection)
* no preoperative intestinal barrier dysfunction
* patients voluntarily participated in this study and signed an informed consent form.

Exclusion Criteria

* Patients or their families refused to participate in this study
* chronic inflammatory diseases (e.g. inflammatory bowel disease, chronic hepatitis, chronic pancreatitis, chronic peptic ulcer, etc.)
* history of antibiotic administration in the last 2 weeks
* severe cognitive impairment and other inability to cooperate preoperative neoadjuvant radiotherapy
* combined with severe hepatic, renal, and cardiac insufficiency patients.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Second Affiliated Hospital of Kunming Medical University

OTHER

Sponsor Role lead

Responsible Party

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Weiming Li

Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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weiming Li

Role: CONTACT

13114225597

Other Identifiers

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PJ-2024-124

Identifier Type: -

Identifier Source: org_study_id

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