Standardizing Method and Development of Normal Values to Measure Human Small Intestinal and Colonic Permeability
NCT ID: NCT04262310
Last Updated: 2021-03-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2019-10-11
2021-02-26
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Study Aims
To obtain normative data (median, 10th and 90th percentile) as well as inter-individual coefficient of variation (COV, assessed by \[SD/mean\]) with approximately 15 participants in each age group: 18-30, 31-45, 46-60, and 60-70 years old. To assess intra-individual COV \[assessed by \[SD/mean\]. To assess effect of standard diets containing 16.25 or 32.5 g fiber/day during the two 24 hour periods before and during the measurement of permeability
Small Bowel and Colonic Permeability Test
small bowel and colonic permeability based on oral probe molecules and urine excretion in 60 healthy white, female and male adults aged 18-70y
Interventions
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Small Bowel and Colonic Permeability Test
small bowel and colonic permeability based on oral probe molecules and urine excretion in 60 healthy white, female and male adults aged 18-70y
Eligibility Criteria
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Inclusion Criteria
* Non-Obese
* Non-pregnant
* Caucasian
* BMI \<30kg/m2
Exclusion Criteria
* Hypertension
* BMI ≥30kg/m2
* Chronic NSAID use (\>3 days/week)
18 Years
70 Years
ALL
Yes
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Michael Camilleri, MD
Principal Investigator
Principal Investigators
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Michael Camilleri, MD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic
Rochester, Minnesota, United States
Countries
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Related Links
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Mayo Clinic Clinical Trials
Other Identifiers
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19-008541
Identifier Type: -
Identifier Source: org_study_id
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