Association Between Confocal Laser Endomicroscopic (CLE) Features and Gastric Mucosal Microbiome

NCT ID: NCT02063932

Last Updated: 2014-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-12-31

Brief Summary

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There might be a correlation between gastric mucosal microbiome and mucosal pattern visualized by confocal laser endomicroscope.

Detailed Description

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The gastric mucosal microbiome plays a pivotal role in a series of diseases, such as the H.pylori infection. We hypothesized that mucosal patterns, here visualized by confocal endomicroscopy, may constitute specific microbiome niches.

Conditions

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Mucosal Microbiome H.Pylori Intestinal Metaplasia Gastric Neoplasia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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endomicroscopy

endomicroscopy, targeted biopsy and 16s rRNA gene sequencing

Intervention Type OTHER

Interventions

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endomicroscopy, targeted biopsy and 16s rRNA gene sequencing

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients scheduled for gastroendoscopy examination
* Aged between 18 and 80 years old

Exclusion Criteria

* Antibiotic, probiotic or prebiotic usage within 2months
* Esophageal, gastric or duodenal cancer or other malignancy
* History of upper GI tract surgery
* Coagulopathy or bleeding disorders
* Allergy to fluorescein sodium
* Pregnant or breast-feeding (for females)
* Impaired renal function
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shandong University

OTHER

Sponsor Role lead

Responsible Party

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Yanqing Li

Vice president of Qilu Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Gastroenterology, Qilu Hospital, Shandong University

Jinan, Shandong, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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Yanqing Li, MD. PhD.

Role: primary

86-531-82169236 ext. 82169508

Other Identifiers

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2014SDU-QILU-G02

Identifier Type: -

Identifier Source: org_study_id

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