Home
Clinical Trials
Post-Trial Tuberculosis Case ...

Post-Trial Tuberculosis Case Finding: A Substudy of CoVPN 3008

Last Updated: 2026-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

5694 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-09-13

Study Completion Date

2025-05-21

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This substudy aims to identify cases of tuberculosis after the CoVPN 3008 clinical trial is completed.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Tuberculosis Diagnostic Trial of CAD4TB Screening Alone Compared to CAD4TB Screening Combined With a CRP Triage Test, Both Followed by Confirmatory Xpert MTB/RIF Ultra in Communities of Lesotho and South Africa

NCT05526885

Tuberculosis

COMPLETED NA

Tuberculosis Prevention for HIV Infected Adults

NCT00057122

HIV Infections Tuberculosis

COMPLETED PHASE3

Evaluation of a Rapid Point-of-Care Serological Triage Test for Active TB

NCT04752592

Tuberculosis, Pulmonary

COMPLETED NA

Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence

NCT03512249

Tuberculosis, Pulmonary

ACTIVE_NOT_RECRUITING PHASE2

Comparative Effectiveness/Implementation of TB Case Finding in Rural South Africa

NCT02808507

Tuberculosis

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This observational substudy will involve participants from the CoVPN 3008 trial, regardless of their HIV status, to study tuberculosis (TB). At the start, all participants will be screened for TB, even if they have no symptoms. They will receive chest x-rays and provide sputum samples for TB testing using Xpert Ultra, smear microscopy, and culture.

The study has two main groups. Group 1 includes participants with confirmed TB, and Group 2 includes participants without TB who will act as controls.

Participants with confirmed TB will start treatment and have a first follow-up visit on Day 4 to reassess TB symptoms and collect blood samples. A second follow-up visit will take place at week 26 to evaluate their treatment progress, clinical outcomes, and TB status, ensuring they receive the necessary care.

Participants without TB will have a single follow-up visit on Day 4 to reassess TB symptoms and collect blood samples. The study aims to identify potential biomarkers of TB by analyzing blood samples from both cases and controls, focusing on gene expression linked to TB, including hidden (subclinical) TB.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Tuberculosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Confirmed TB

Participants with confirmed TB will start treatment and have a follow-up visit soon after to check their TB symptoms again and collect blood samples. They will also have a second follow-up visit at week 26 to assess their treatment progress and TB status.