The TRICURE EU Pivotal Study

NCT ID: NCT06581471

Last Updated: 2025-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-29

Study Completion Date

2030-12-30

Brief Summary

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Prospective, multi-center study to assess safety and performance of the TRiCares Topaz Tricuspid Valve Replacement System

Detailed Description

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The study is a multi-center, prospective single arm study designed to evaluate the safety and performance of the TRiCares Topaz Tricuspid Valve Replacement System.

Conditions

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Tricuspid Valve Regurgitation Heart Valve Disease Cardiovascular Diseases

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Transcatheter Tricuspid Valve Replacement

Treatment with the TRiCares Topaz Tricuspid Transcatheter Valve Replacement System

Group Type EXPERIMENTAL

Transcatheter Tricuspid Valve Replacement

Intervention Type DEVICE

Replacement of the tricuspid valve through a transcatheter approach

Interventions

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Transcatheter Tricuspid Valve Replacement

Replacement of the tricuspid valve through a transcatheter approach

Intervention Type DEVICE

Other Intervention Names

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TRiCares Topaz Tricuspid Valve Replacement System

Eligibility Criteria

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Inclusion Criteria

* Adult patients
* Tricuspid regurgitation grade 3 (severe) on a scale of 0 (none) to 5 (torrential)
* Institutional Heart Team evaluates patient as being at increased operative risk

Exclusion Criteria

* Patient in need of emergent intervention
* Patient who is hemodynamically unstable
* Anatomical contraindications for implantation with study device
* Patient who is currently participating in another clinical investigation where the primary endpoint was not reached yet
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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TRiCares

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jörg Hausleiter, MD

Role: PRINCIPAL_INVESTIGATOR

LMU Munich

Locations

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Algemeen Stedelijk Ziekenhuis

Aalst, , Belgium

Site Status RECRUITING

ZNA Middelheim

Antwerp, , Belgium

Site Status RECRUITING

UZ Brussel

Brussels, , Belgium

Site Status RECRUITING

Cliniques Universitaires Saint-Luc UCL

Brussels, , Belgium

Site Status RECRUITING

Centre hospitalier universitaire CHU de Liège

Liège, , Belgium

Site Status NOT_YET_RECRUITING

AZ Delta

Roeselare, , Belgium

Site Status RECRUITING

University Medical Center of the Johannes Gutenberg University Mainz

Mainz, , Germany

Site Status NOT_YET_RECRUITING

Ludwig Maximilian University Hospital

Munich, , Germany

Site Status RECRUITING

Countries

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Belgium Germany

Central Contacts

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Esther Gerteis

Role: CONTACT

+41796015318

Facility Contacts

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Liesbeth Rosseel, MD

Role: primary

003253766730

Stefan Verheye, MD

Role: primary

Stijn Lochy, MD

Role: primary

Joelle Kefer, MD

Role: primary

Patrizio Lancellotti, MD

Role: primary

Maarten Vanhaverbeke, MD

Role: primary

Phiipp Lurz, MD

Role: primary

Jörg Hausleiter, MD

Role: primary

Other Identifiers

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2401

Identifier Type: -

Identifier Source: org_study_id

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