Neurophysiological Changes After Perturbation-based Training in Older Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

88 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-04-18

Study Completion Date

2026-10-14

Brief Summary

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This is an assessor-blinded neurophysiological study. Participants will be randomly assigned to a perturbation-based training (PBT) or a walking (control) group. Changes in postural stability and neurophysiology in the brain following PBT compared to walking exercise without perturbation will be investigated.

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Detailed Description

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A total of 88 participants will be randomly assigned to two groups receiving perturbation-based training (PBT) or walking exercise without perturbation (control). Written informed consent will be obtained from participants prior to the baseline assessment. The study will be reported and conducted in line with the CONSORT statement. Participants will be recruited via convenience sampling in the local community. Both groups will receive two sessions of treadmill walking at their comfortable speed. Perturbations will be induced during treadmill walking only for the PBT group. As informed from previous literature, two sessions of PBT could have improved postural stability for up to 1.5 years. Between-group differences in behavioural and MRI findings will be examined before and after training to identify training-induced changes in postural stability, brain structures, and functional connectivities. Retention of the changes in the postural stability will be assessed four months after the training period. Incidents of falls will be followed up for 12 months after training.

Conditions

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Falling Community Dwelling Older Adults Postural Stability Brain Connectivity Brain Structure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants will be randomly assigned to PBT or active control group.

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Perturbation-based balance training group

This group will receive two sessions of treadmill walking at their comfortable speed involving perturbations

Group Type EXPERIMENTAL

Perturbation-based balance training (PBT)

Intervention Type BEHAVIORAL

It will be a two-session training with each session lasting for approximately an hour. Perturbations will be induced during treadmill walking. Participants will be instructed to recover their balance and continue walking after the perturbations.

Control

This group will receive two sessions of treadmill walking at their comfortable speed involving no perturbations

Group Type PLACEBO_COMPARATOR

Walking exercise (control)

Intervention Type BEHAVIORAL

It will be a two-session training with each session lasting for approximately an hour. The same training duration and format will be used as the PBT group, except that no perturbations will be induced during the treadmill walking.

Interventions

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Perturbation-based balance training (PBT)

It will be a two-session training with each session lasting for approximately an hour. Perturbations will be induced during treadmill walking. Participants will be instructed to recover their balance and continue walking after the perturbations.

Intervention Type BEHAVIORAL

Walking exercise (control)

It will be a two-session training with each session lasting for approximately an hour. The same training duration and format will be used as the PBT group, except that no perturbations will be induced during the treadmill walking.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Aged ≥ 60 years old
* Community-dwelling
* Right-handed
* Able to communicate effectively in Cantonese or Mandarin
* Able to walk independently on level ground for ≥ 30 minutes
* Abbreviated Mental Test (Hong Kong version) score ≥ 6

Exclusion Criteria

* Metal implants (e.g. pacemaker, artificial cochlea)
* Uncorrected vision or hearing impairment
* Osteoporosis
* Hip or knee replacement within the last year
* Musculoskeletal, cardiovascular, mental, or neurological disorders (such as Parkinson's disease) which can affect MRI examination, balance control, or exercise participation.

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes