Using Navigation to Improve Accuracy of Maxillary Balloon Sinusotomy

NCT ID: NCT06567821

Last Updated: 2025-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2/PHASE3

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-04

Study Completion Date

2025-12-31

Brief Summary

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The purpose of the research is to examine the effectiveness of navigation in maxillary sinus balloon dilation for the treatment of chronic maxillary rhinosinusitis.

Detailed Description

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The purpose of the research is to examine the effectiveness of navigation in maxillary sinus balloon dilation for the treatment of chronic maxillary rhinosinusitis. Adult patients (18 and over) with a confirmed diagnosis of chronic maxillary rhinosinusitis without nasal polyposis (CRSwNP) will undergo maxillary balloon sinusotomy. Block randomization will be performed to determine which side will receive balloon sinusotomy with navigation and which will have balloon sinusotomy using traditional anatomic landmarks. Participants will be followed for approximately 1 month post-procedure for a total study participation time of approximately 3 months.

Conditions

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Chronic Maxillary Rhinosinusitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

This is a prospective randomized single blinded study. A block randomization will be performed to randomize each candidate to determine which side will receive a balloon sinusotomy without navigation and which side will receive balloon sinusotomy with the assistance of navigation. Each person has a set of sinuses on the right side and a set of sinuses on the left side. One side will be randomized to the balloon dilation with navigation while the other side will be performed with balloon dilation without navigation.
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors
The procedure will be recorded for subsequent blinded review.

Interventions

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RELIEVA SPINPLUS® NAV Balloon Sinusplasty System

The non-navigated device being used is the RELIEVA SPINPLUS® Balloon Sinusplasty System and the navigated device being used is the RELIEVA SPINPLUS® NAV Balloon Sinusplasty System. Both devices being used are standard devices that are currently FDA approved and used in practice for sinus dilation at Cedars-Sinai Medical Center.

Intervention Type DEVICE

Other Intervention Names

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RELIEVA SPINPLUS® Balloon Sinusplasty System

Eligibility Criteria

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Inclusion Criteria

* Adults 18 years of age or older
* Candidate for primary endoscopic sinus surgery (ESS) for chronic maxillary rhinosinusitis without nasal polyposis (CRSwNP)
* Failed medical (non-surgical) therapy

Exclusion Criteria

* History of previous sinus surgery
* Presence of nasal polyps
* Extensive sinonasal osteogeneis
* Cystic fibrosis
* Presence of sinonasal tumors
* Any records flagged "break the glass" or "research opt out."
* Any additional finding which in the opinion of the investigator precludes patient from participating in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cedars-Sinai Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Dennis Tang

Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cedars Sinai

Los Angeles, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Shruti Shantharam

Role: CONTACT

5627873255

Facility Contacts

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Dennis M Tang, MD

Role: primary

310-423-1220

Other Identifiers

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STUDY00003097

Identifier Type: -

Identifier Source: org_study_id

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