Canadian Health Economics, Outcome, and Effectiveness Comparison of Treatment in Patients With Chronic Rhinosinusitis

NCT ID: NCT01455948

Last Updated: 2024-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-02-29

Study Completion Date

2012-11-30

Brief Summary

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The economic, patient related outcome, and effectiveness of balloon sinuplasty in the treatment of CRS patients with frontal and other sinus disease in the Canadian healthcare environment is not known at this time. This study will evaluate the impact of balloon sinuplasty and traditional FESS treatment on CRS patients.

Detailed Description

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Conditions

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Chronic Rhinosinusitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

SINGLE

Participants

Study Groups

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Balloon Sinuplasty™ System

Group Type ACTIVE_COMPARATOR

Relieva Balloon Sinuplasty™ System

Intervention Type DEVICE

Catheter-based devices used to dilate blocked paranasal sinus ostia (openings).

Functional Endoscopic Sinus Surgery

Group Type ACTIVE_COMPARATOR

Functional Endoscopic Sinus Surgery

Intervention Type PROCEDURE

Specialized probes are used to cannulate closed ostia (openings), and small forceps are used to resect periostial bone and tissue to enlarge the sinus ostia.

Interventions

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Relieva Balloon Sinuplasty™ System

Catheter-based devices used to dilate blocked paranasal sinus ostia (openings).

Intervention Type DEVICE

Functional Endoscopic Sinus Surgery

Specialized probes are used to cannulate closed ostia (openings), and small forceps are used to resect periostial bone and tissue to enlarge the sinus ostia.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Documented diagnosis of unilateral or bilateral Chronic Rhinosinusitis based on the European Position Paper on Rhinosinusitis and Nasal Polyps (2) with at least frontal and maxillary sinus involvement
* Documented failed medical treatment of CRS
* Eighteen (18) to sixty-five (65) years of age
* Employed in full time position or equivalent
* Planned FESS for treatment of CRS
* Must have an American Society of Anesthesiologists physical status of P3 classification or less
* Able to provide informed consent by signing the informed consent document at the screening visit prior to any study activities
* Able to read and understand English

Exclusion Criteria

* Previous sinonasal surgery
* Pregnant
* Cystic Fibrosis
* Diagnosed immotile cilia syndrome
* Samter's Triad
* Diagnosed immunodeficiency syndrome
* Diagnosed fungal sinusitis
* Concurrent septoplasty or turbinate surgery
* Diagnosed recurrent acute sinusitis
* Current smoker
* Presence of grade 2 or greater nasal polyps
* Sinonasal tumors or obstructive lesions
* History of substance or alcohol abuse within the past 12 months
* Investigator's opinion that the subject should not be in the study such as any conditions that could compromise the wellbeing of the patient or integrity of the study or prevent the patient from meeting or performing study requirements
* Participation in a research study 30 days prior to surgery
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Acclarent

INDUSTRY

Sponsor Role collaborator

Integra LifeSciences Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ian Witterick, MD, MSc

Role: PRINCIPAL_INVESTIGATOR

Mount Sinai Hospital, Toronto, Ontario, Canada

Locations

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Hamilton General Hospital

Hamilton, Ontario, Canada

Site Status

St. Joseph's Health Centre

London, Ontario, Canada

Site Status

Ottawa Hospital - Civic Campus

Ottawa, Ontario, Canada

Site Status

Trillium Health Centre

Toronto, Ontario, Canada

Site Status

Toronto East General

Toronto, Ontario, Canada

Site Status

St. Michael's Hospital

Toronto, Ontario, Canada

Site Status

Mount Sinai Hospital

Toronto, Ontario, Canada

Site Status

St. Joseph's Health Centre

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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JJMC-001

Identifier Type: -

Identifier Source: org_study_id

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