Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
NCT ID: NCT06129552
Last Updated: 2024-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
300 participants
OBSERVATIONAL
2023-12-19
2027-12-31
Brief Summary
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Detailed Description
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1. Investigate differences in epithelial and basal cell functions and differentiation characteristics.
2. Characterize the differences in epithelial cell populations and gene expression patterns. Also include an AR subset, to see if changes are specific for CRSwNP or more general for type 2 inflammatory disease of the upper airways.
3. Investigate basal cell activation via different environmental triggers through TLR stimulation.
4. Look at the genetic imprinting of basal cells before and after being exposed to specific triggers.
5. Investigate whether the secreted proteins from basal cells are chemotactic for other cell populations.
6. Investigate the interaction between basal and regulatory T cells.
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Healthy controls
Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
Conchotomy involves the reduction or removal of hypertrophic nasal turbinates, aesthetic nose surgery is a surgical procedure that aims to enhance the appearance of the nose, while functional endoscopic sinus surgery is a minimally invasive procedure focused on treating sinus conditions by removing obstructions and improving sinus drainage.
CRSwNP patients
Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
Conchotomy involves the reduction or removal of hypertrophic nasal turbinates, aesthetic nose surgery is a surgical procedure that aims to enhance the appearance of the nose, while functional endoscopic sinus surgery is a minimally invasive procedure focused on treating sinus conditions by removing obstructions and improving sinus drainage.
AR patients
Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
Conchotomy involves the reduction or removal of hypertrophic nasal turbinates, aesthetic nose surgery is a surgical procedure that aims to enhance the appearance of the nose, while functional endoscopic sinus surgery is a minimally invasive procedure focused on treating sinus conditions by removing obstructions and improving sinus drainage.
Interventions
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Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
Conchotomy involves the reduction or removal of hypertrophic nasal turbinates, aesthetic nose surgery is a surgical procedure that aims to enhance the appearance of the nose, while functional endoscopic sinus surgery is a minimally invasive procedure focused on treating sinus conditions by removing obstructions and improving sinus drainage.
Eligibility Criteria
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Inclusion Criteria
* Males and females
Exclusion Criteria
* AR
* Smoker, or \< 1-year ex-smoker
* Underlying systematic pathology (Morbus Wegener or Churg Strauss Syndrome for example)
18 Years
ALL
Yes
Sponsors
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Regeneron Pharmaceuticals
INDUSTRY
Universitaire Ziekenhuizen KU Leuven
OTHER
Responsible Party
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Locations
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Peter Hellings
Leuven, , Belgium
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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S67788
Identifier Type: -
Identifier Source: org_study_id
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