Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps
NCT ID: NCT06459622
Last Updated: 2024-06-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
102 participants
INTERVENTIONAL
2024-07-31
2025-05-31
Brief Summary
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Detailed Description
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Steroids are widely used as the most effective medicine in nasal polyposis. Although oral corticosteroids are one of the frequently used treatments in the management of chronic rhinosinusitis with nasal polyps (CRSwNP), there is lack of effective means of predicting corticosteroid sensitivity in those patients. It was reported that the overall sensitivity rates of corticosteroid therapy to nasal polyps( NP) were only between 53.8% and 80%.. Many reports stated that serum and tissue interleukeine 25 (IL 25) and serum and tissue eosinophalia are good predictors to the response of CRSwNP to oral corticosteroids.
Interleukeine 25(IL-25), an important epithelial-derived proinflammatory cytokine, plays various roles in different inflammatory and allergic diseases, such as asthma and atopic dermatitis .
Hong et al demonstrated that the levels of IL-25 in NP tissues and in serum, as well as the NP endoscopic scores, were significantly elevated in the corticosteroid-sensitive patients compared with the non-sensitive ones. In general, eosinophilic NPs are pharmacologically glucocorticoid responsive, but non-eosinophilic or neutrophilic CRSwNP is frequently resistant to steroid treatment.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
DIAGNOSTIC
NONE
Study Groups
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Sensitive to corticosteroids
Patients who are sensitive to corticosteroids have high serum IL-25
Serum IL_25 and eosinophils in nasal polyp tisuee
Serum IL-25 and eosinophils in nasal polyps tisuer obtained and measured to identify the sensitivity of nasal polyps to corticosteroids
Non sensitive to corticosteroids
Patients who aren't sensitive to corticosteroids have low serum IL-25
Serum IL_25 and eosinophils in nasal polyp tisuee
Serum IL-25 and eosinophils in nasal polyps tisuer obtained and measured to identify the sensitivity of nasal polyps to corticosteroids
Interventions
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Serum IL_25 and eosinophils in nasal polyp tisuee
Serum IL-25 and eosinophils in nasal polyps tisuer obtained and measured to identify the sensitivity of nasal polyps to corticosteroids
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2- previous nasal and sinus surgery.
3-Allergic Fungal rhinosinusitis.
4-Unilateral rhinosinusitis.
5- Antrochoanal polyps or cystic fibrosis.
18 Years
80 Years
ALL
Yes
Sponsors
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Assiut University
OTHER
Katrina Atef Habashy
OTHER
Responsible Party
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Katrina Atef Habashy
Predictive factors in response of chronic rhinosinusitis with nasal polyps to corticosteroids
Central Contacts
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References
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Shin HW, Kim DK, Park MH, Eun KM, Lee M, So D, Kong IG, Mo JH, Yang MS, Jin HR, Park JW, Kim DW. IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2015 Jun;135(6):1476-85.e7. doi: 10.1016/j.jaci.2015.01.003. Epub 2015 Feb 25.
Study Documents
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Document Type: Clinical Study Report
View DocumentOther Identifiers
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Chronic rhinosinusitis
Identifier Type: -
Identifier Source: org_study_id
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