The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2018-06-30

Brief Summary

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Previous studies have demonstrated that the eosinophilic inflammation of nasal mucosa is associated with the uncontrolled condition of chronic rhinosinusitis after surgery. However, the definition of the eosinophilic chronic rhinosinusitis is not very clear. Japanese researchers have designed a scoring system to diagnose eosinophilic chronic rhinosinusitis. In this study, the investigators hope to examine the practicability of this scoring system and have a better knowledge of eosinophilic chronic rhinosinusitis in china.The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.

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Detailed Description

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The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.

Conditions

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Sinusitis Nasal Polyps

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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postoperational CRS

observe the symptoms and endoscopic appearance

sinonasal outcome test-22

Intervention Type DIAGNOSTIC_TEST

Evaluate the nasal mucosal inflammation condition and overall quality-of-life of CRS patients

Interventions

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sinonasal outcome test-22

Evaluate the nasal mucosal inflammation condition and overall quality-of-life of CRS patients

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Lund-Kennedy endoscopic score

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of chronic rhinosinusitis according to European position paper of rhinosinusitis and nasal polyps 2007.

Exclusion Criteria

* Immunodeficiency diseases, history of head and/or facial trauma, cancer or organ transplant recipients.
* Pregnancy or lactation.
* Acute respiratory tract infection within one month before the study.
* Patients without pathological samples.
* Antrochoanal polyp and cyst of the paranasal sinuses.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No