MedDataX Logo

The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis

NCT ID: NCT03374124

Last Updated: 2017-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-01-31

Study Completion Date

2018-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Previous studies have demonstrated that the eosinophilic inflammation of nasal mucosa is associated with the uncontrolled condition of chronic rhinosinusitis after surgery. However, the definition of the eosinophilic chronic rhinosinusitis is not very clear. Japanese researchers have designed a scoring system to diagnose eosinophilic chronic rhinosinusitis. In this study, the investigators hope to examine the practicability of this scoring system and have a better knowledge of eosinophilic chronic rhinosinusitis in china.The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Sinusitis Nasal Polyps

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Chronic rhinosinusitis Eosinophil Surgery Diagnosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

postoperational CRS

observe the symptoms and endoscopic appearance

sinonasal outcome test-22

Intervention Type DIAGNOSTIC_TEST

Evaluate the nasal mucosal inflammation condition and overall quality-of-life of CRS patients

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

sinonasal outcome test-22

Evaluate the nasal mucosal inflammation condition and overall quality-of-life of CRS patients

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Lund-Kennedy endoscopic score

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Diagnosis of chronic rhinosinusitis according to European position paper of rhinosinusitis and nasal polyps 2007.

Exclusion Criteria

* Immunodeficiency diseases, history of head and/or facial trauma, cancer or organ transplant recipients.
* Pregnancy or lactation.
* Acute respiratory tract infection within one month before the study.
* Patients without pathological samples.
* Antrochoanal polyp and cyst of the paranasal sinuses.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Jianbo Shi

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Jianbo Shi

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Jianbo Shi, doctor

Role: STUDY_DIRECTOR

Ent department, the first affiliated hospital, Sun Yat-sen University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

the first affiliated hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Jianbo Shi, doctor

Role: CONTACT

Phone: 8602087333733

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Fenghong Chen, doctor

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

20171019

Identifier Type: -

Identifier Source: org_study_id