Comparison Between Serratus Anterior Plane Block and Erector Spinae Plane Block in Coarctectomy

NCT ID: NCT06567275

Last Updated: 2025-07-02

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 28 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-08-24
• Study Completion Date: 2025-04-15

Brief Summary

Pain is considered to be subjective, however, in children, it is believed to be felt rather than expressed because they often depend on the caregiver for their safety and well-being.

There is significant pain after thoracotomy surgery because of pleural and muscular damage, ribcage disruption, and intercostal nerve damage during surgery, which if not effectively managed, will lead to various systemic complications; pulmonary (atelectasis, pneumonia, and stasis of bronchial secretions), cardiovascular (increased oxygen consumption and tachycardia), musculoskeletal (muscle weakness), increased neurohormonal response and prolonged hospital stay. So adequate and sufficient post-operative analgesia for pediatric patients is mandatory.

The use of highly potent opioids for pediatric cardiothoracic anesthesia has gained widespread popularity during the last 20 years. In addition to the important advantage of hemodynamic stability, the large-dose opioid-based anesthetic techniques also blunt the stress response, However, large doses can cause oversedation, respiratory depression, and prolonged mechanical ventilation after surgery.

serratus anterior plane block guided by ultrasound was developed by Blanco et al, it is a novel technique in the management of pain following thoracic procedures.

Local anesthetic inserted into these planes will spread throughout the lateral chest wall, resulting in paresthesia of the T2 through T9 dermatomes of the anterolateral thorax. It became popular because it is much safer and easily administered than other alternative regional techniques such as thoracic paravertebral and thoracic epidural blocks.

The Erector Spinae Plane Block (ESPB) is also one of the recently known pain-controlling techniques used in pediatric cardiothoracic surgeries. It became popular because it is much safer and easily administered than other alternative regional techniques such as thoracic paravertebral and thoracic epidural blocks. Chin et al. documented the cadaveric spread of local anesthetic and noted that, radiologically, the local anesthetic spread extended 3 or 4 levels cranially and caudally from the site of injection.

These two blocks have been compared in a study by wang HJ et al in patients undergoing radical mastectomy.

To our knowledge, the comparison of serratus Plane Block versus erector spinae plane block in aortic coarctectomy operations in pediatric patients has not been investigated yet. This has encouraged the performance of the present study.

Conditions

Aortic Coarctation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

erector spinae plane block

Ultrasound-guided erector spinae plane block will be done by injecting 0.4 ml/kg (1:1 solution of bupivacaine 0.25% and lidocaine 1%).

Group Type: EXPERIMENTAL

Erector Spinae Plane Block

Intervention Type: PROCEDURE

Ultrasound-guided erector spinae plane block will be done by injecting 0.4 ml/kg (1:1 solution of bupivacaine 0.25% and lidocaine 1%)

serratus anterior plane block

Ultrasound-guided serratus anterior plane block will be done by injecting 0.4 ml/kg (1:1 solution of bupivacaine 0.25% and lidocaine 1%).

Group Type: EXPERIMENTAL

Serratus Anterior Plane Block

Intervention Type: PROCEDURE

Ultrasound-guided serratus anterior plane block will be done by injecting 0.4 ml/kg (1:1 solution of bupivacaine 0.25% and lidocaine 1%)

Interventions

Erector Spinae Plane Block

Ultrasound-guided erector spinae plane block will be done by injecting 0.4 ml/kg (1:1 solution of bupivacaine 0.25% and lidocaine 1%)

Intervention Type: PROCEDURE

Serratus Anterior Plane Block

Ultrasound-guided serratus anterior plane block will be done by injecting 0.4 ml/kg (1:1 solution of bupivacaine 0.25% and lidocaine 1%)

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Age: 3 months-2 years.
• RACHS-1 score 3.
• Patients undergoing aortic coarctectomy operation with Lateral thoracotomy incision.

Exclusion Criteria

• Patients whose parents or legal guardians refuse to participate.
• Preoperative mechanical ventilation.
• Preoperative inotropic drug infusion.
• Perioperative cardiopulmonary arrested patients.
• Patients undergoing aortic coarctectomy operation with midline sternotomy incision.
• History of mental retardation or delayed development that may interfere with pain intensity assessment.
• Known or suspected coagulopathy. (PT < 75% of control)
• Any congenital anomalies or any infection at the site of injection.
• Known or suspected allergy to any of the studied drugs.
• liver enzymes elevated more than the normal values.
• Renal function impairment (Creatinine value more than 1.2mg/dl or BUN more than 20mg/dl).
• Heart failure patients
• Redo patients and previous catheter dilatations

• Minimum Eligible Age: 3 Months
• Maximum Eligible Age: 2 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Ahmed Awad Eissa Roman

Principle investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Wafaa M Elsadeq

Role: STUDY_DIRECTOR

Professor of Anesthesia, Pain Management, and Surgical ICU Faculty

Locations

Abu Elreish Hospital

Cairo, , Egypt

Countries

Egypt

References

Gado AAM, Atia MAM, Roman AA, Elsadeq WM, Jaccoub VF. Analgesic efficacy of ultrasound guided erector spinae plane block versus serratus anterior plane block in pediatric patients undergoing aortic coarctectomy; a randomized controlled study. BMC Anesthesiol. 2025 Jul 30;25(1):370. doi: 10.1186/s12871-025-03256-y.

Reference Type: DERIVED

PMID: 40739624 (View on PubMed)

Other Identifiers

Nerve blocks in coarctectomy

Identifier Type: -

Identifier Source: org_study_id