CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs
NCT ID: NCT06565546
Last Updated: 2026-01-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
100 participants
INTERVENTIONAL
2025-01-29
2026-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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CYP2D6 genotype testing-treatment
CYP2D6 genotype testing performed preoperatively with results used to guide prescribing of opioid analgesics during the postoperative period to control pain. In addition, participants will receive standard of care postoperative pain medications.
Opioid pain medication prescribed based on CYP2D6 genotype testing PLUS Acetaminophen and Gabapentin
CYP2D6 genotype testing for assessment of medication metabolism to guide prescription of postoperative pain medication
CYP2D6 genotype testing-control
CYP2D6 genotype testing performed preoperatively, results will be delayed until after operative procedure. Participants will receive standard of care postoperative pain medication prescriptions for pain management.
Acetaminophen and Gabapentin: standard postoperative pain medications
Participants will receive standard postoperative pain medications
Interventions
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Opioid pain medication prescribed based on CYP2D6 genotype testing PLUS Acetaminophen and Gabapentin
CYP2D6 genotype testing for assessment of medication metabolism to guide prescription of postoperative pain medication
Acetaminophen and Gabapentin: standard postoperative pain medications
Participants will receive standard postoperative pain medications
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* primary ventral hernia repair (VHR) without a mesh
* emergency operative procedure
* receiving chronic opioid therapy (defined as use of opioids on most days for \>3 months)
* allergy to opioids
* women of childbearing potential who have a positive pregnancy result as part of their standard pre-surgical workup
18 Years
90 Years
ALL
No
Sponsors
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University of Florida
OTHER
Responsible Party
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Principal Investigators
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Jana Sacco, MD
Role: PRINCIPAL_INVESTIGATOR
Assistant Professor
Locations
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University of Florida Jacksonville
Jacksonville, Florida, United States
Countries
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Other Identifiers
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202401069
Identifier Type: -
Identifier Source: org_study_id
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