The Outcome of Injured Cervical Spinal Cord with Uncontrolled Swelling Under Duraplasty

NCT ID: NCT06552507

Last Updated: 2025-02-10

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 104 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-03-01
• Study Completion Date: 2026-08-01

Brief Summary

Overall Objective: To assess whether incorporating duraplasty alongside bony decompression enhances motor function outcomes in individuals following Traumatic Spinal Cord Injury (TSCI).

Rationale for Research:

In a systematic review, individuals suffering from cervical Traumatic Spinal Cord Injuries (TSCIs) identified specific priorities for improvement in their quality of life. These priorities encompassed enhanced arm and hand function, improved bladder and bowel control, sexual function, and the nurturing of personal relationships with their families and friends.

In this context, the investigators posit that augmenting standard treatment with expansion duraplasty has the potential to address several critical aspects of TSCI. Our hypothesis centers on the idea that the incorporation of duraplasty into the treatment regimen can lead to a reduction in spinal cord compression, an enhancement in Spinal Cord Perfusion Pressure (SCPP), an amelioration in spinal cord metabolism, and a mitigation of inflammation at the injury site. The investigatorsanticipate that these physiological and metabolic enhancements will contribute to increased neuronal survival, ultimately resulting in improved motor outcomes. These improved motor outcomes, in turn, are expected to translate into enhanced limb function, superior bladder and bowel control, and an overall improvement in the quality of life for the patients.

Our investigative focus encompasses a comprehensive examination of the impact of duraplasty on various facets of spinal cord physiology, metabolism, inflammation, motor and sensory performance, and Health-Related Quality of Life (HRQoL) measures. These HRQoL measures encompass aspects such as hand function, ambulation, bladder and bowel function, as well as the mental, emotional, and social well-being of the patients.

In the north area of R.O.C, individuals with TSCI are initially admitted to Linkou Chang Guan Memorial Hospital, where they typically undergo surgery involving spinal instrumentation (e.g., screws and rods) to address deformities and instability. Bony decompression, typically carried out through laminectomy, is a common surgical intervention aimed at addressing the adverse effects of bony compression on the spinal cord. It is worth noting that a significant majority of surgeons (ranging from 85% to 96%) advocate for bony decompression as a primary treatment for TSCI, as recommended by the National Institute for Health and Care Excellence (NICE) guidelines in 2016. However, the effectiveness of bony decompression in improving outcomes following TSCI remains a topic of debate and uncertainty, largely due to the absence of robust evidence from randomized controlled trials (RCTs).

Our proposal suggests that bony decompression in isolation may offer only partial relief to the swollen and injured spinal cord, which continues to experience compression against the dura. This may explain the persisting uncertainty surrounding the benefits of bony decompression in TSCI treatment. Achieving adequate cord decompression through surgical intervention assumes particular importance in this context, given the lack of pharmaceutical treatments proven to enhance outcomes in individuals with acute and severe TSCI. While the administration of methylprednisolone initially showed promise, subsequent trials, observational studies, and meta-analyses have cast doubt on its efficacy and raised concerns about potential harm.

The management of TSCI in the R.O.C is characterized by considerable variation among major trauma centers, encompassing diverse practices related to factors such as target blood pressure, choice of anesthetic agents, extent of monitoring (including the use of arterial and central lines), and timing of surgery. To circumvent these controversies and differences in practice, the "The outcome of Injured cervical Spinal Cord with Uncontrolled Swelling under Duraplasty" trial has been meticulously designed in a single major trauma center to allow participating surgeon can follow the same protocol about time to surgery and medically management.

The "The outcome of Injured cervical Spinal Cord with Uncontrolled Swelling under Duraplasty" trial was conceived with the aim of addressing these critical questions surrounding TSCI management, ultimately seeking to improve the outcomes and quality of life for individuals grappling with this challenging condition.

Conditions

Spine Injury; Cord Injury, Spinal; Cord Infarction Spinal; Incomplete Spinal Cord Injury; Complete Spinal Cord Injury

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Laminectomy with Duroplasty

Duroplasty

Group Type: EXPERIMENTAL

Duroplasty

Intervention Type: PROCEDURE

The investigators open the dura from midline and repaired with fish mouth for dura augmentation

Laminectomy only

laminectomy without duroplasty

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Duroplasty

The investigators open the dura from midline and repaired with fish mouth for dura augmentation

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Age ≥18 years
• Severe cervical (C2 - T1) traumatic spinal cord injury (AIS grade A-C)
• Deemed to require and be suitable for surgery that includes laminectomy or diskectomy by local surgeon
• Surgery within 72 hours of traumatic spinal cord injury
• Able to provide informed consent or consultee declaration or proxy consent

Exclusion Criteria

• Life-limiting or rehabilitation-restricting co-morbidities
• Thoracic or lumbar traumatic spinal cord injury
• Probable dural tear due to injury
• Other central nervous system disease

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Chang Gung Memorial Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

Li Ying Ching Ying-Ching Li, Dr.

Role: CONTACT

johnhunter0823@gmail.com

886953723572

References

van Daalen Wetters T, Coffino P. Cultured S49 mouse T lymphoma cells. Methods Enzymol. 1987;151:9-19. doi: 10.1016/s0076-6879(87)51005-9. No abstract available.

Reference Type: BACKGROUND

PMID: 3501530 (View on PubMed)

Farmer C, Fenu E, O'Flynn N, Guthrie B. Clinical assessment and management of multimorbidity: summary of NICE guidance. BMJ. 2016 Sep 21;354:i4843. doi: 10.1136/bmj.i4843. No abstract available.

Reference Type: BACKGROUND

PMID: 27655884 (View on PubMed)

Liu J, Liu P, Ma Z, Mou J, Wang Z, Sun D, Cheng J, Zhang D, Xiao J. The effects of aging on the profile of the cervical spine. Medicine (Baltimore). 2019 Feb;98(7):e14425. doi: 10.1097/MD.0000000000014425.

Reference Type: BACKGROUND

PMID: 30762749 (View on PubMed)

Other Identifiers

2312250059

Identifier Type: -

Identifier Source: org_study_id