Bloodstream Infection of Carbapenem-Resistant Proteus Mirabilis

NCT ID: NCT06542965

Last Updated: 2024-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

67 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2023-01-01

Brief Summary

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This study aims to determine the clinical characteristics, risk factors, and resistance mechanisms of patients with carbapenem-resistant P. mirabilis bacteremia.Patients with P. mirabilis growth in blood culture samples sent to bacteriology laboratory between 2018 and 2021 were retrospectively analyzed. Patients meeting the inclusion criteria were divided into carbapenem-resistant and carbapenem- susceptible groups. The investigators recorded demographic data, clinical features, and laboratory findings. Resistance genes were investigated in carbapenem-resistant isolates using PCR.

Detailed Description

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Patients with P. mirabilis growth in blood culture who met the study criteria were divided into two groups as carbapenem susceptible and resistant according to carbapenem antibiogram results. Patients with carbapenem-resistant P. mirabilis (CRPM) growth in blood culture were included in the case group and patients with carbapenem- susceptible P. mirabilis (CSPM) growth in blood culture were included in the control group.

Demographic characteristics of the patients, concomitant chronic diseases, Charlson comorbidity index (CCI), hospital and intensive care unit (ICU) hospitalization and number of days in the last year, history and type of invasive intervention in the last three months (surgical-invasive), history of antibiotic use in the last three months and types of antibiotics used (Penicillin, cephalosporin, quinolone, carbapenem, tigecycline, colistin, aminoglycoside), hospitalization unit, total length of hospitalization, sample collection unit, growth result and antibiogram, clinical and laboratory data of the day of growth, sepsis and septic shock evaluated according to systemic inflammatory response syndrome (SIRS) criteria, 30-day mortality and patient outcome information were recorded.

Carbapenemase-producing gene regions were investigated by Polymerase Chain Reaction (PCR) in accessible samples of patients with carbapenem-resistant P. mirabilis growth in blood cultures.

Conditions

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Proteus Mirabilis Infection Bacteremia Carbapenem Resistant Bacterial Infection

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Case (Patients with carbapenem-resistant P. mirabilis)

Patients with carbapenem-resistant P. mirabilis (CRPM) growth in blood culture were included in the case group

Non-Interventional Research

Intervention Type OTHER

Non-Interventional Research

Control (Patients with carbapenem- susceptible P. mirabilis)

Patients with carbapenem- susceptible P. mirabilis (CSPM) growth in blood culture were included in the control group

Non-Interventional Research

Intervention Type OTHER

Non-Interventional Research

Interventions

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Non-Interventional Research

Non-Interventional Research

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Inpatients aged 18 years and older
* P. mirabilis growth in blood cultures

Exclusion Criteria

* Samples taken in emergency departments, outpatient clinics, day treatment units
* Recurrent growths of the same patient
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dokuz Eylul University

OTHER

Sponsor Role lead

Responsible Party

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Cağlar Iirmak

Principal Investigator, Medical Specialists in Infectious Diseases

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Çağlar IRMAK

Role: PRINCIPAL_INVESTIGATOR

Dokuz Eylul University

Locations

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Dokuz Eylül University

Izmir, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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DEU-INF-IRMAK-1

Identifier Type: -

Identifier Source: org_study_id

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