Nasopharynx Microbiota Component and in Vitro Cytokines Production in Coronavirus Disease (COVID-19)

NCT ID: NCT04708912

Last Updated: 2021-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-15

Study Completion Date

2021-04-01

Brief Summary

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The investigators will study nasopharunx microbiota composition, RNA sequences and in vitro cytokines production by peripheral blood cells of COVID-19 patients (both mild-moderate and severe cases) (comparing with convalescent patients and healthy controls).

Detailed Description

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The investigators will compare study parameters (basal) between mild-moderate and severe COVID-19 patients and with other study groups (i.e. convalescent and healthy controls). Nasopharunx microbiota dysbiosis, in vitro cytokines production profile, and peripheral blood flocytometric results of the four study groups will be compared.

In vitro cytokines production will be studied and compared in Nill (No antigens) and Mitojen (Cocktail of antigens) pre-prepared test tubes.

Conditions

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Covid19

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1

Mild-Moderate COVID-19

Observation

Intervention Type OTHER

The study parameters will be obtained at the time of recuirement (Basal)

2

Severe COVID-19

Observation

Intervention Type OTHER

The study parameters will be obtained at the time of recuirement (Basal)

3

Convalsent (COVID-19)

Observation

Intervention Type OTHER

The study parameters will be obtained at the time of recuirement (Basal)

4

Healthy persons

No interventions assigned to this group

Interventions

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Observation

The study parameters will be obtained at the time of recuirement (Basal)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Ability to give a written consent

Exclusion Criteria

* In ability to give a written consent
* Using of medications that affect the results of study parameters
* Presence of malignancy or tuberculosis
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Başakşehir Çam & Sakura City Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Mehmet Hursitoglu

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mehmet Hursitoglu, MD

Role: PRINCIPAL_INVESTIGATOR

Basaksehir Cam and sakura Sehir Hospital

Locations

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Bakirkoy Dr.sadi Konuk Training and Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status RECRUITING

Bakirkoy Dr.sadi Konuk Training and Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status RECRUITING

Countries

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Turkey (Türkiye)

Central Contacts

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Mehmet Hursitoglu, MD

Role: CONTACT

+902129096000 ext. 20527

References

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Microbiota and viral infections

Reference Type RESULT

Other Identifiers

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8796

Identifier Type: -

Identifier Source: org_study_id

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