Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome

NCT ID: NCT06537648

Last Updated: 2025-05-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-08-02
• Study Completion Date: 2025-05-09

Brief Summary

The investigators are assessing acceptability, appropriateness, and feasibility of an remote choreographed exercise intervention using validated scales alongside qualitative data among young adults with Down Syndrome. Participants will take part in a 12-week exercise program with two 35-minute session per week delivered in a group setting. The aims of the project are to:

• Assess the feasibility of a 12 week remotely delivered group dance intervention.
• Assess changes in aerobic fitness and cognitive function in response to a 12 week remotely delivered group dance intervention.
• Assess the intensity and total energy expenditure of remotely delivered group dance sessions.

Detailed Description

The incidence of Alzheimer's disease for persons with Down syndrome exceeds 90%, and physical activity engagement has demonstrated potential to delay onset of Alzheimer's disease for this population. Adults with Down syndrome participate in less physical activity than their counterparts without disability, partially due to unique barriers preventing engagement in typical modalities of physical activity for this population. Dance, which is characterized by rhythmic physical movements offers the potential for social engagement, and stimulation of brain functions may offer a reasonable alternative to traditional physical activity modalities. However, empirical evidence to support the feasibility of a remotely delivered group dance intervention and evaluation of the intensity and energy expenditure achieved by a dance intervention for adults with Down syndrome are currently unavailable and will be the focus of the proposed pilot trial. Adults with Down will be asked to attend 35 minute remotely delivered (Zoom®) group dance sessions twice weekly across 12 weeks to assess the acceptability, appropriateness, and feasibility of the intervention, energy expenditure achieved during the exercise sessions, and evaluate change in aerobic fitness and cognitive function after 12 weeks.

Conditions

Down Syndrome; Physical Inactivity

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome

Participants will be asked to play attend 35 minute, remotely delivered, group exercise classes using choreographed exercise twice a week for 12 weeks.

Group Type: EXPERIMENTAL

Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Program

Intervention Type: BEHAVIORAL

Adults with Down syndrome will be asked to attend 35 minute, remotely delivered (Zoom®) group dance sessions twice weekly across 12 weeks. All sessions will be directed by an instructor experienced in leading 35 minute, group remote exercise sessions for individuals with intellectual disability as part of the ongoing exercise program for individuals with intellectual disability offered by the Division for Physical Activity and Weight Management.

Interventions

Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome Program

Adults with Down syndrome will be asked to attend 35 minute, remotely delivered (Zoom®) group dance sessions twice weekly across 12 weeks. All sessions will be directed by an instructor experienced in leading 35 minute, group remote exercise sessions for individuals with intellectual disability as part of the ongoing exercise program for individuals with intellectual disability offered by the Division for Physical Activity and Weight Management.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Diagnosis of Down syndrome
• Sufficient functional ability to communicate through spoken language
• No plans to relocate outside the study area over the next 12 weeks
• Possession of a personal device that allows for connectivity to the internet and participate in 2x weekly group video calls
• Ability to participate in Moderate to vigorous physical activity

Exclusion Criteria

• Serious medical risk (e.g., cancer, recent heart attack, stroke, pregnancy, angioplasty as determined by the research staff
• unwilling to participate in outcomes assessments
• uninterested

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 64 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Kansas Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University Of Kansas Medical Center

Kansas City, Kansas, United States

Countries

United States

Other Identifiers

T32AG078114

Identifier Type: NIH

Identifier Source: org_study_id

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