Benefits of Exergames on Neurocognitive Functions in Adults Suffering From Depression

NCT ID: NCT06536530

Last Updated: 2025-07-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2027-01-31

Study Completion Date

2029-03-31

Brief Summary

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The purpose of this study is to analyse the changes derived from exergames (videogames that include cognitive and physical stimulation simultaneously), in terms of cognitive functioning, psychomotor abilities, and its neural substrate, in adults suffering from depression.

Detailed Description

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The experiment will consist in a randomized three-arms controlled study. After being informed about the study and potential risks, and given written informed consent, adult participants with depression will be randomly distributed into three experimental groups: an intervention group that will train with exergames, an active control group that will train only with cognitive games, and a passive control group or wait-list.

Cognitive Functions will be evaluated in three different moments: before the training intervention, after the intervention, and three months after finishing the training intervention.

Researchers will collect cognitive-behavioral and neural information (event-related potentials), and performing analysis of variance to compare the outcomes of the diverse groups at the three different time points, scientists will analyse the benefits of exergames on cognition.

Conditions

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Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This project consists in a three-arms parallel-group randomized study to measure the benefits of exergames on cognition, in adults suffering from depression. Researchers will compare three different interventions (training with an exergame, which combines cognitive and physical stimulation, training with a cognitive game, and a wait-list condition), by randomizing participants to each group with equal probability.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants
This experiment is a single-blind design, where participants will be blind to the intervention, but researchers will not be blind to intervention allocation.

Study Groups

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Exergame-Based Training

Participants train with exergames (video games that include cognitive and physical training simultaneously), The training regime consists of 40-50 min sessions, two sessions per week, for a total of eight weeks of individual training.

Group Type EXPERIMENTAL

Exergame-Based Training

Intervention Type BEHAVIORAL

40-50 min sessions, two sessions per week, for a total of eight weeks.

Cognitive-Based Training

Participants will train only with cognitive video games. The training regime consists of 40-50 min sessions, two sessions per week, for a total of eight weeks of individual training.

Group Type ACTIVE_COMPARATOR

Cognitive-Based Training

Intervention Type BEHAVIORAL

40-50 min sessions, two sessions per week, for a total of eight weeks.

Wait-List

Participants will not train with any program and they will not assist to any specific session.

Group Type PLACEBO_COMPARATOR

Wait-List

Intervention Type BEHAVIORAL

Participants will not train with any program and they will not assist to any specific session or intervention

Interventions

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Exergame-Based Training

40-50 min sessions, two sessions per week, for a total of eight weeks.

Intervention Type BEHAVIORAL

Cognitive-Based Training

40-50 min sessions, two sessions per week, for a total of eight weeks.

Intervention Type BEHAVIORAL

Wait-List

Participants will not train with any program and they will not assist to any specific session or intervention

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* A sufficient level of education to understand study procedures and be able to communicate with site personnel

Exclusion Criteria

* Participants suffering from depression with comorbidities (bipolar disorder, obsessive-compulsion disorder, neurological disorder, or traumatic brain injury) will be excluded.
* \<20/60 vision with or without correction
* Inability to complete the activities
* Communication problems
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MAP Institute

OTHER

Sponsor Role lead

Responsible Party

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PhD Prof. Eloisa Ruiz-Marquez

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Eloisa Ruiz-Marquez

Role: CONTACT

643862849 ext. 0034

References

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Ruiz-Marquez E. Neurophysiology of executive cognitive functions under depression. Explor Neurosci. 2025;4:100696. https://doi.org/10.37349/en.2025.100696

Reference Type BACKGROUND

Ruiz-Marquez E. Protocol for measuring the benefits of exergames on executive functions under depression through a randomized multi-arm controlled experiment. Explor Neurosci. 2024;3:564-83. https://doi.org/10.37349/en. 2024.00068

Reference Type BACKGROUND

Ruiz-Marquez, E. (2023). Protocol for measuring the benefits of exergames on executive functions under depression through a randomized multi-arm controlled experiment. Preprint. Open Science Framework.https://doi.org/10.31234/osf.io/m7s2t_v1

Reference Type BACKGROUND

Ruiz-Marquez, E. (2025). Neurophysiology of executive cognitive functions under depression. Preprint. Open Science Framework. https://doi.org/10.37349/en.2025.100696

Reference Type BACKGROUND

Ruiz-Marquez, E.,(2024). MUDgame. Measuring the Benefits of an Exergame-based intervention on Neuro-Cognitive Functions in adults suffering from Depression. A Randomized Multi-Arm Controlled Experiment. Project. Open Science Framework. https://doi.org/10.17605/OSF.IO/YBDCT

Reference Type BACKGROUND

Ruiz-Marquez, E. (2023). MUDgame. Measuring the Benefits of an Exergame-based intervention on Neuro-Cognitive Functions in adults suffering from Depression. A Randomized Multi-Arm Controlled Experiment. Preregistration. Open Science Framework. https://doi.org/10.17605/OSF.IO/Z4S9Q

Reference Type BACKGROUND

Other Identifiers

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z4s9q

Identifier Type: -

Identifier Source: org_study_id

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