Electroacupuncture Treatment of Behavioral and Psycological Symptoms in Patients With Alzheimer's Disease

NCT ID: NCT06523309

Last Updated: 2024-07-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-07-30

Study Completion Date

2027-10-31

Brief Summary

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This study aims to establish a prospective case registration research platform for electroacupuncture in treating behavioral and psychological symptoms in patients with mild to moderate Alzheimer's disease, and to investigate the dose-effect relationship and cost-effectiveness of electroacupuncture for these symptoms.

Detailed Description

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To establish a prospective case registration research platform aimed at treating mild to moderate Alzheimer's disease patients presenting with behavioral and psychological symptoms. This platform will document the electroacupuncture treatment process, conduct regular assessments using neuropsychiatric questionnaires (NPI) and the Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change Scale (ADAS-CGIC), and compare the effects of different parameters, treatment frequency, and duration of electroacupuncture on therapeutic outcomes for various behavioral and psychological symptoms in Alzheimer's disease patients. Furthermore, it aims to investigate the influencing factors of electroacupuncture treatment for behavioral and psychological symptoms.

Conditions

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BPSD (Behavioral and Psycological Symptoms of Dementia) Alzheimer's Dementia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Affective symptom group

A group of Alzheimer's patients showing emotional symptoms such as anxiety, depression, apathy, etc.

Electroacupuncture treatment

Intervention Type OTHER

Electroacupuncture treatment consists of conventional acupuncture and electrical stimulation. After acupuncture, the electrical stimulation is continuously stimulated.

Psychotic symptom group

A group of Alzheimer's patients showing psychotic symptoms such as delusions, hallucinations, etc.

Electroacupuncture treatment

Intervention Type OTHER

Electroacupuncture treatment consists of conventional acupuncture and electrical stimulation. After acupuncture, the electrical stimulation is continuously stimulated.

Hyperactivity symptom group

A group of Alzheimer's patients showing hyperactivity symptoms such as irritability, aggression, aberrant motor behaviour, etc.

Electroacupuncture treatment

Intervention Type OTHER

Electroacupuncture treatment consists of conventional acupuncture and electrical stimulation. After acupuncture, the electrical stimulation is continuously stimulated.

Euphoric symptom group

A group of Alzheimer's patients showing euphpric symptoms.

Electroacupuncture treatment

Intervention Type OTHER

Electroacupuncture treatment consists of conventional acupuncture and electrical stimulation. After acupuncture, the electrical stimulation is continuously stimulated.

Interventions

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Electroacupuncture treatment

Electroacupuncture treatment consists of conventional acupuncture and electrical stimulation. After acupuncture, the electrical stimulation is continuously stimulated.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Meet the diagnostic criteria for AD in the NIA-AA standard;
2. Clinical dementia rating scale ≤2 points;
3. Accompanied by at least one psychobehavioral symptom, NPI:frequency × degree ≥1 point;
4. Sign informed consent.

Exclusion Criteria

1.There are contraindications for acupuncture treatment, such as the tendency of acupoint bleeding or allergy to metal
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Guang'anmen Hospital of China Academy of Chinese Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Bao-Hui Jia

Director of rehabilitation Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Baohui Jia

Role: PRINCIPAL_INVESTIGATOR

Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Locations

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Beijing United Family Rehabilitation Hospital

Beijing, Beijing Municipality, China

Site Status

China-Japan Friendship Hospital

Beijing, Beijing Municipality, China

Site Status

Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Beijing, Beijing Municipality, China

Site Status

Xuanwu Hospital of Capital Medical University

Beijing, Beijing Municipality, China

Site Status

Beijing Geriatric Hospital

Beijing, Beijing Municipality, China

Site Status

Fujian University of Traditional Chinese Medicine

Fuzhou, Fujian, China

Site Status

The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine

Harbin, Heilongjiang, China

Site Status

Countries

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China

Central Contacts

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Baohui B Jia

Role: CONTACT

010-88001454

Ran Li

Role: CONTACT

18801094908

Facility Contacts

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Dongmei D Li

Role: primary

13717850887

Rongxing R Shi

Role: primary

18610153099

Ran Li

Role: primary

010-88001454

Aihong A Zhou

Role: primary

010-83192333

Jihui J Lv

Role: primary

13520094838

Ying Xu

Role: primary

0591-22861815

Li Zhang

Role: primary

18646026517

Other Identifiers

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2024-076-KY-01

Identifier Type: -

Identifier Source: org_study_id

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