Methylprednisolone Combined Electric-acupuncture on Cognitive Function
NCT ID: NCT02535039
Last Updated: 2016-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1/PHASE2
80 participants
INTERVENTIONAL
2015-10-31
2016-12-31
Brief Summary
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Through comparing the operation of cerebral oxygen saturation, blood biochemical indexes, Montreal cognitive assessment scale (MOCA) on cognitive function in patients with grade indexes, such as observation of methylprednisolone combined electric acupuncture treatment of elderly patients with general anesthesia early after the operation, the influence of cognitive function.
Detailed Description
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1 day before the surgery, postoperative 1 day, 2 days, 3 days, 7 days the MOCA scale to assess cognitive function after surgery for the patient.(T0) prior to the induction and bi (T1), 24 h after surgery (T2) and 48 h after surgery (T3) extraction in patients with venous blood, adopts the method of enzyme-linked immunosorbent (ELISA) determination of serum IL - 1 beta, IL - 6, Aβ1-42, p- Tau concentration.In rSO2 intraoperative continuous monitoring, and calculate the average rSO2, intraoperative rSO2 down the biggest percentage compared with basic value rSO2 % of Max.And record the occurrence of adverse reactions to special circumstances.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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Placebo
Before anesthesia induction, with electroacupuncture can cave, inside the closed cavity, foot three mile point, cupping model for continuous wave type, current pulse frequency of 2 hz, adjust the intensity of the electric acupuncture, with patients complained of needle feeling, can accept no pain and discomfort.Intraoperative sustained electroacupuncture.The same volume of physiological saline will be given.
Physiological saline
The same volume of physiological saline will be given in Placebo group
Methylprednisolne
in the anaesthesia to 1 mg/kg intravenous methylprednisolone, methylprednisolone continuous use 1 mg/kg \* d until the third day after surgery.Before anesthesia induction, with electroacupuncture can cave, inside the closed cavity, foot three mile point, cupping model for continuous wave type, current pulse frequency of 2 hz, adjust the intensity of the electric acupuncture, with patients complained of needle feeling, can accept no pain and discomfort.Intraoperative sustained electroacupuncture.
Methylprednisolone
Anaesthesia in giving 1 mg/kg intravenous methylprednisolone, methylprednisolone (1 mg/kg \* d for application to the third day after surgery
Interventions
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Methylprednisolone
Anaesthesia in giving 1 mg/kg intravenous methylprednisolone, methylprednisolone (1 mg/kg \* d for application to the third day after surgery
Physiological saline
The same volume of physiological saline will be given in Placebo group
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* The American Society of anesthesiologists (American Society of Anesthesiology, ASA) class Ⅱ \~ III
* With a primary culture of above (including elementary school)
* There is no history of drug allergy.
Exclusion Criteria
* Taking sedatives or antidepressants history
* Insulin dependent diabetes
* Coronary heart disease
* Cerebral infarction
* Preoperative MOCA score less than 26 points
65 Years
75 Years
ALL
Yes
Sponsors
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Shengjing Hospital
OTHER
Responsible Party
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Yanchao Yang
resident doctor
Principal Investigators
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Junchao Zhu, doctor
Role: STUDY_DIRECTOR
professor
Locations
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Shengjing hospital of China medical university
Shenyang, Liaoning, China
Countries
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Central Contacts
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Facility Contacts
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Yanchao Yang, Master
Role: primary
Junchao Zhu, Doctor
Role: backup
Other Identifiers
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Shengjing hospital
Identifier Type: -
Identifier Source: org_study_id