Kissing As a Protective Factor Against Acidic PH in Saliva

NCT ID: NCT06501729

Last Updated: 2024-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-07-30

Study Completion Date

2025-11-20

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The pH of saliva can be acidic or alkaline; When it is acidic, the tooth enamel is demineralized, that is, weakened. Additionally, bacteria in the mouth can increase and cause infections such as cavities. This occurs when we consume sugary or fermented drinks, such as soda or beer.

The intention of the research team is to give some of these drinks to the study participants and verify the decrease in salivary pH. Next, a group of people will be asked to kiss their partner on the mouth, and then the pH will be measured again to see if it increases, that is, if it stops being acidic faster than in the group that did not kiss.

The aim is to demonstrate that kissing on the mouth between two people can protect teeth from cavities by rapidly increasing the pH of saliva after it has decreased to become acidic.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The goal of this intervention study will be to determine if oral kissing between two people can increase salivary pH more quickly after drinking artificial juices, soft drinks, or (non-alcoholic) beers. It will also be studied whether the pH restoration time is faster when only one person kisses one of the named drinks or when both people do it. The main questions that are intended to be answered are the following:

* Is the act of kissing on the mouth capable of increasing the pH of saliva more quickly than physiologically after consuming a sugary or fermented drink that has decreased it?
* Is the increase in salivary pH after an oral kiss more accelerated when only one person consumes sugary or fermented drinks than when both people do so? The investigators will measure the basal pH of all participants before providing them with one of the drinks (artificial fruit juice, soda, or non-alcoholic beer). The researchers will then give the drinks and measure the decrease in salivary pH in all groups. Control group participants will not kiss; They will only wait for the salivary pH to neutralize physiologically. The rest of the couples will be divided into two groups: the group in which only one person in the couple consumes the sugary or fermented drink, and the group in which both people in the couple do so.

Saliva pH measurements will be performed, after initiation and consumption of the drinks, every 5 minutes for up to 40 minutes. That is, until the restoration of salivary pH is ensured in all groups.

Participants:

* They will be between 18 and 30 years old to reduce the probability of consuming medications that alter salivary pH.
* They should not be taking medications that alter the pH of saliva.
* They must be in good health.
* They should not have abscesses in the oral cavity.
* They must have good oral health according to the loss proposed and the observed index.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dental Caries Tooth Demineralization Teeth Erosion Limited to the Enamel

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Saliva Hydrogen-Ion Concentration dental caries

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

The couples in the control group will not kiss; they will only wait for the salivary pH to neutralize physiologically. The other couples will be divided into two groups: the group in which only one person in the couple consumes the sugary or fermented drink, and the group in which both people in the couple do so.
Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control

The couples in the control group will not kiss; they will only wait for the salivary pH to neutralize physiologically.

Group Type NO_INTERVENTION

No interventions assigned to this group

Only one person consumes the drink

the group in which only one person in the couple consumes the sugary or fermented drink and they kiss

Group Type EXPERIMENTAL

Kiss

Intervention Type OTHER

Participants will kiss with their partners for 40 seconds. The kiss will be on the mouth.

Both people consume the drink

In this group, both people will consume the drinks and then kiss.

Group Type EXPERIMENTAL

Kiss

Intervention Type OTHER

Participants will kiss with their partners for 40 seconds. The kiss will be on the mouth.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Kiss

Participants will kiss with their partners for 40 seconds. The kiss will be on the mouth.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* They must be in good health
* They must have good oral health according to the raised loss and observed index.
* They will be between 18 and 30 years old to reduce the probability of consuming medications that alter salivary pH.

Exclusion Criteria

* Be taking medications that alter the pH of saliva.
* Have abscesses in the oral cavity
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Universidad Catolica Santiago de Guayaquil

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Fernando Armijos Briones

Teaching researcher

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

School of Dentistry of the Catholic University Santiago de Guayaquil

Guayaquil, Guayas, Ecuador

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Ecuador

References

Explore related publications, articles, or registry entries linked to this study.

Uma E, Theng KS, Yi LLH, Yun LH, Varghese E, Soe HHK. Comparison of Salivary pH Changes after Consumption of Two Sweetened Malaysian Local Drinks among Individuals with Low Caries Experience: A Pilot Study. Malays J Med Sci. 2018 Jul;25(4):100-111. doi: 10.21315/mjms2018.25.4.10. Epub 2018 Aug 30.

Reference Type BACKGROUND
PMID: 30914852 (View on PubMed)

Armijos Briones M, Aguila Gaibor M, Bermudez Velasquez A. Kissing as a Protective Factor Against Decreased Salivary pH: Protocol for a Randomized Clinical Trial. JMIR Res Protoc. 2025 Jul 17;14:e65253. doi: 10.2196/65253.

Reference Type DERIVED
PMID: 40674724 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

598

Identifier Type: -

Identifier Source: org_study_id