Correlation Between Optic Nerve Sheath Diameter and Neurological Deficit in Adult Patients With Suspected Ischemic Stroke
NCT ID: NCT06492681
Last Updated: 2025-09-16
Study Results
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Basic Information
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COMPLETED
19 participants
OBSERVATIONAL
2024-09-01
2025-09-01
Brief Summary
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Detailed Description
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III. Objectives Estimate the correlation between the ultrasound measurement of the optic nerve sheath diameter and the side of neurological focus in the physical examination of adult patients evaluated in emergency departments.
Determine the sensitivity and specificity of the ultrasound measurement of the optic nerve sheath diameter for predicting the side of neurological focus.
IV. Methodology
Study design:
A observational study will be conducted in a secondary care hospital.
Population and sample:
Adult patients (≥18 years) presenting to the emergency department with neurological symptoms, such as headache, altered level of consciousness, motor or sensory deficit, among others, will be included. Patients with contraindications for ocular ultrasound or with a history of previous ocular surgery will be excluded.
Procedures:
1. Informed consent will be obtained from patients who meet the inclusion criteria.
2. A neurological physical examination will be performed to identify the side of neurological focus.
3. The optic nerve sheath diameter will be measured using ultrasound with a high-frequency linear transducer (7.5-12 MHz).
4. Demographic, clinical, and ultrasound data will be recorded for the patients.
Data analysis:
The correlation between the ultrasound measurement of the optic nerve sheath diameter and the side of neurological focus will be calculated using Pearson's or Spearman's correlation coefficient, depending on the distribution of the data. Additionally, sensitivity, specificity, positive and negative predictive values, and 95% confidence intervals will be calculated to determine the diagnostic utility of the ultrasound measurement of the optic nerve sheath diameter in identifying the side of neurological focus.
V. Ethical considerations The ethical guidelines established by the Declaration of Helsinki will be followed, and the privacy and confidentiality of patients will be protected. The protocol will be approved by the hospital's Research Ethics Committee before its implementation.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* CT scan negative to hemorrhagic stroke
* Informed consent
Exclusion Criteria
* Patients with ocular surgery
18 Years
ALL
No
Sponsors
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Clinica Mexico
OTHER
Responsible Party
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Jose Ivan Rodriguez de Molina Serrano
Head of Research and Critical Care Medicine
Locations
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Clinica Mexico
Piedras Negras, Coahuila, Mexico
Countries
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References
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Lau T, Ahn JS, Manji R, Kim DJ. A Narrative Review of Point of Care Ultrasound Assessment of the Optic Nerve in Emergency Medicine. Life (Basel). 2023 Feb 15;13(2):531. doi: 10.3390/life13020531.
Nathani A, Ghamande SA, Kambhampati S, Anderson B, Lohse M, White HD. The Use of POCUS-Obtained Optic Nerve Sheath Diameter in Intracerebral Hemorrhage. POCUS J. 2023 Nov 27;8(2):170-174. doi: 10.24908/pocus.v8i2.16563. eCollection 2023.
Rajajee V, Vanaman M, Fletcher JJ, Jacobs TL. Optic nerve ultrasound for the detection of raised intracranial pressure. Neurocrit Care. 2011 Dec;15(3):506-15. doi: 10.1007/s12028-011-9606-8.
Bauerle J, Lochner P, Kaps M, Nedelmann M. Intra- and interobsever reliability of sonographic assessment of the optic nerve sheath diameter in healthy adults. J Neuroimaging. 2012 Jan;22(1):42-5. doi: 10.1111/j.1552-6569.2010.00546.x. Epub 2010 Dec 1.
Kimberly HH, Shah S, Marill K, Noble V. Correlation of optic nerve sheath diameter with direct measurement of intracranial pressure. Acad Emerg Med. 2008 Feb;15(2):201-4. doi: 10.1111/j.1553-2712.2007.00031.x.
Other Identifiers
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00001
Identifier Type: -
Identifier Source: org_study_id
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