Characterization of Myeloproliferative Neoplasia With a Mutated IDH, SRSF2 or SF3B1 Allele (CARPEDIEM)

NCT ID: NCT06481345

Last Updated: 2024-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-25

Study Completion Date

2026-05-31

Brief Summary

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Retrospective study assessing the impact of IDH1/2, SRSF2 or SF3B1 mutations on event free survival of MPN patients

Detailed Description

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Patients with a diagnosis of MPN and a mutation of IDH1/2, SRSF2 or SF3B1 will be included. Clinical and biological characterisation at diagnosis, as well as evlution will be recorded. Event free survival will be assessed in each group (event = thrombosis, transformation to mylofibrosis/acute leukemia, death).

Conditions

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Myeloproliferative Disorders

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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MPN patients with IDH1/2 mutation

No interventions assigned to this group

MPN patients with SRSF2 mutation

No interventions assigned to this group

MPN patients with SF3B1 mutation

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with MPN diagnosis
* Mutation in IDH1/2, SRSF2 or SF3B1

Exclusion Criteria

* Unable to consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Brest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Chu Brest

Brest, , France

Site Status

Countries

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France

Other Identifiers

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29BRC24.0154 - CARPEDIEM

Identifier Type: -

Identifier Source: org_study_id

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