Predictive Factors for Survival in Aggressive Meningiomas

NCT ID: NCT05793034

Last Updated: 2025-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-07

Study Completion Date

2027-01-07

Brief Summary

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The investigators plan to collect clinical and molecular data, including ICH, PCR, NGS and methylome, from patients operated on for grade 2 or grade 3 meningioma. The purpose of the study is to identify reliable and easy-to-assess predictive factors for recurrence and survival after surgery.

Detailed Description

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Conditions

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Meningioma Meningioma Atypical Anaplastic Meningioma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Biological biomarker assessment

FFPE tumor tissue will be processed with a number of molecular biology techniques

Group Type OTHER

Biological biomarker assessment

Intervention Type DIAGNOSTIC_TEST

IHC, PCR, NGS, methylome

Interventions

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Biological biomarker assessment

IHC, PCR, NGS, methylome

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. Patient operated for atypical (grade 2) meningioma; or
2. Patient operated for anaplastic (grade 3) meningioma;
3. Timeframe for surgery, 1999-2019

Exclusion Criteria

1\) Patient lost at follow-up
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Fondazione Policlinico Universitario A. Gemelli IRCCS

Rome, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Alessandro Olivi, MD

Role: CONTACT

+39 06 3015 4120

Rina Di Bonaventura, MD

Role: CONTACT

+39 06 3015 1

Facility Contacts

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Alessandro Olivi, MD

Role: primary

+39 06 3015 4120

Roberto Pallini, MD, PhD

Role: backup

+39 06 3015 5414

Other Identifiers

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3459

Identifier Type: -

Identifier Source: org_study_id

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