Influence of Air Quality on the Development and Progression of Premature Coronary Artery Disease
NCT ID: NCT06464042
Last Updated: 2024-06-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
4272 participants
OBSERVATIONAL
2024-05-23
2025-07-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Premature Coronary Artery Disease
Patients between 18 and 40 years old diagnosed with coronary artery disease, including: ST-elevation myocardial infarction (STEMI), non-ST-elevation acute coronary syndrome (NSTE-ACS), unstable angina, stable angina, MINOCA or silent angina
No interventions assigned to this group
Non Coronary Artery Disease
Patient without coronary artery disease
For each case, 3 controls matched by age (±1 year), sex, postal code, and/or primary care center will be included. To avoid the selection of controls that could be associated with an overestimation of exposure to cardiovascular risk factors, the controls will be recruited from the preoperative unit and selected from subjects who have undergone minor clinical procedures (vasectomy, hernia repair, phimosis, prominent ear correction, tubal ligation, euthyroid thyroid nodule, plastic surgery, lipomas, vocal cord cysts, among others), or from the trauma service, selecting those attending for fractures or sprains. This approach ensures a complete medical history along with analytical values in their electronic medical records
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Women and men between 18 and 40 years old with no diagnosis or history of CAD or other coronary disease coded in their medical records
Exclusion Criteria
CONTROL
* Present with non-ischemic coronary diseas.
* Have a serious condition that affects or decreases life expectancy.
* Do not have a postal code or primary care center assigned in their medical records in Galicia
18 Years
40 Years
ALL
No
Sponsors
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Fundacin Biomedica Galicia Sur
OTHER
Conselleria de Saúde Pública de Galicia
UNKNOWN
Conselleria de Medio Ambiente, Territorio e Vivenda de Galicia
UNKNOWN
pablo Juan-Salvadores
OTHER
Responsible Party
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pablo Juan-Salvadores
Principal Investigator
Principal Investigators
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Pablo Juan-Salvadores, Pharma, PhD
Role: PRINCIPAL_INVESTIGATOR
Instituto de Investigación Sanitaria Galicia Sur (IIS Galicia Sur)
Locations
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Hospital Álvaro Cunqueiro
Vigo, Pontevedra, Spain
Countries
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Central Contacts
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Facility Contacts
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References
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Juan-Salvadores P, Veiga C, Jimenez Diaz VA, Guitian Gonzalez A, Iglesia Carreno C, Martinez Reglero C, Baz Alonso JA, Caamano Isorna F, Romo AI. Using Machine Learning Techniques to Predict MACE in Very Young Acute Coronary Syndrome Patients. Diagnostics (Basel). 2022 Feb 6;12(2):422. doi: 10.3390/diagnostics12020422.
Juan-Salvadores P, Jimenez Diaz VA, Iglesia Carreno C, Guitian Gonzalez A, Veiga C, Martinez Reglero C, Baz Alonso JA, Caamano Isorna F, Iniguez Romo A. Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up. J Cardiovasc Dev Dis. 2022 Mar 11;9(3):82. doi: 10.3390/jcdd9030082.
Juan-Salvadores P, Jimenez Diaz VA, Rodriguez Gonzalez de Araujo A, Iglesia Carreno C, Guitian Gonzalez A, Veiga Garcia C, Baz Alonso JA, Caamano Isorna F, Iniguez Romo A. Clinical Features and Long-Term Outcomes in Very Young Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries. J Interv Cardiol. 2022 Jul 30;2022:9584527. doi: 10.1155/2022/9584527. eCollection 2022.
Chen R, Yin P, Meng X, Liu C, Wang L, Xu X, Ross JA, Tse LA, Zhao Z, Kan H, Zhou M. Fine Particulate Air Pollution and Daily Mortality. A Nationwide Analysis in 272 Chinese Cities. Am J Respir Crit Care Med. 2017 Jul 1;196(1):73-81. doi: 10.1164/rccm.201609-1862OC.
Orellano P, Reynoso J, Quaranta N, Bardach A, Ciapponi A. Short-term exposure to particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), and ozone (O3) and all-cause and cause-specific mortality: Systematic review and meta-analysis. Environ Int. 2020 Sep;142:105876. doi: 10.1016/j.envint.2020.105876. Epub 2020 Jun 23.
Kirwa K, Szpiro AA, Sheppard L, Sampson PD, Wang M, Keller JP, Young MT, Kim SY, Larson TV, Kaufman JD. Fine-Scale Air Pollution Models for Epidemiologic Research: Insights From Approaches Developed in the Multi-ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Curr Environ Health Rep. 2021 Jun;8(2):113-126. doi: 10.1007/s40572-021-00310-y.
Chen SY, Hwang JS, Chan CC, Wu CF, Wu C, Su TC. Urban Air Pollution and Subclinical Atherosclerosis in Adolescents and Young Adults. J Adolesc Health. 2022 Aug;71(2):233-238. doi: 10.1016/j.jadohealth.2022.03.004. Epub 2022 May 7.
Related Links
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Other Identifiers
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SEC/FEC-INV-CLI 23/23
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
CI23-06
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
AirHeart Study
Identifier Type: -
Identifier Source: org_study_id
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