Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?
NCT ID: NCT01536808
Last Updated: 2025-09-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
150 participants
INTERVENTIONAL
2009-04-30
2014-12-31
Brief Summary
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Therefore, the originality of this project is to hypothesize that :
* Diabetes mellitus is often associated with a premature aging syndrome
* Cellular senescence may potentiate the mechanisms that are involved in decreasing myocardial contractility in DM and,
* DM associated to premature aging may increase the risk of developing a cardiomyopathy Thus, the modulation of telomerase activity and the control of telomere length, together with the attenuation of the formation of reactive oxygen species, might represent important new targets in order to develop therapeutic tools in prevention of diabetic cardiomyopathy.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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Type 2 Diabetes Mellitus
Cardiac RMI
Cardiac RMI
Analysis telomere
Analysis telomere
Stress test
Stress test
echocardiography
echocardiography
Interventions
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Cardiac RMI
Cardiac RMI
Analysis telomere
Analysis telomere
Stress test
Stress test
echocardiography
echocardiography
Eligibility Criteria
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Inclusion Criteria
* 40 \< Age \< 55 years old
* oral antidiabetic or insulin treatment
* No symptoms
* Sinus rhythm
* no sign or history of heart disease
* LVEF \> 55%
* Absence of regional left ventricular motion abnormalities.
Exclusion Criteria
* silent ischemia defined as positive exercise test or positive stress echocardiography,
* history of cardiomyopathy or CAD,
* valvular heart disease hemodynamically significant,
* severe renal insufficiency defined as creatinine clearance \< 30 mL/min,
* echocardiographic images unsuitable for quantification,
* type 1 diabetes mellitus,
* Important diabetes mellitus imbalance defined as glycated hemoglobin \> 9% or glycemia \> 3g/L uncontrolled hypertension (\> 180/100 mmHg).
40 Years
55 Years
ALL
No
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Principal Investigators
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Geneviève Dérumeaux, MD
Role: PRINCIPAL_INVESTIGATOR
Hospices Civils de Lyon - Hôpital Louis Pradel
Locations
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Laboratoire d'échocardiographie
Bron, , France
Countries
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References
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Sen I, Trzaskalski NA, Hsiao YT, Liu PP, Shimizu I, Derumeaux GA. Aging at the Crossroads of Organ Interactions: Implications for the Heart. Circ Res. 2025 May 23;136(11):1286-1305. doi: 10.1161/CIRCRESAHA.125.325637. Epub 2025 May 22.
Other Identifiers
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2008.506
Identifier Type: -
Identifier Source: org_study_id
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