Drug Burden Index is Associated With Malnutrition in Community-dwelling Dementia Patients

NCT ID: NCT06447259

Last Updated: 2024-06-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

415 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-20

Study Completion Date

2023-12-10

Brief Summary

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Malnutrition leads to poor clinical outcomes in dementia patients. The investigator aimed to examine the association between drug burden index (DBI) and anticholinergic burden (ACB) scores with nutrition status in community-dwelling older adults with dementia, considering that drugs may contribute malnutrition.

A total of 415 outpatients with dementia, evaluated by Mini Nutrition Assessment test and registered drug information, are included in the study. The investigator calculated the DBI as the sum of all sedatives and anticholinergics taken continuously for at least four weeks prior to admission and evaluated the ACB score.

Practice Impact: Due to accompanying chronic diseases and symptoms, cholinergic and/or sedative-loaded drugs are often prescribed to dementia patients. In this study, İnvestigators emphasized that in addition to the cholinergic loads of the drugs used, their sedative loads and the drug doses they use are also important. Avoiding prescribing these medications to patients with dementia will protect them from malnutrition and its negative consequences.

Detailed Description

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Conditions

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Malnutrition Severe Dementia Drug Use Anticholinergic Toxicity

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of any type of demantia
* Must be able to swallow tablets
* Must be recorded data of medications and doses

Exclusion Criteria

* Psychiatric disorders
* Mild cognitive impairment
* End-stage diseases (renal, liver, cardiac)
* Uncontrolled thyroid functions
Minimum Eligible Age

65 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sultan Keskin Demircan

OTHER_GOV

Sponsor Role lead

Responsible Party

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Sultan Keskin Demircan

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Sultan Keskin Demircan

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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GulhaneTR2

Identifier Type: -

Identifier Source: org_study_id

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