Study Results
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Basic Information
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ENROLLING_BY_INVITATION
NA
30 participants
INTERVENTIONAL
2021-11-01
2025-05-01
Brief Summary
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Detailed Description
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Methods In this prospective study, acute or early hematogenous periprosthetic joint infections (PJIs) will be treated with the modified procedure of Debridement, Antibiotics, Laser irradiation and Implant Retention (DALIR). The investigators compare the completeness of biofilm removal from the implant surface with mechanical cleansing alone and the additional use of Er:YAG laser light. Therefore, the investigators will obtain swab cultures from the implants on three distinct occasions: post-arthrotomy, subsequent to mechanical cleansing, and after Er:YAG laser irradiation. The investigators also compare the success rate of the DALIR procedure with the international literature.
Results The investigators expect, that the prevalence of viable microorganisms obtained from implant surfaces through swab cultures will be considerably diminished after additional Er:YAG laser therapy in comparison to only mechanical cleaning with LavaSurge®. The investigators hope to reach a higher healing rate in relation to comparable studies.
Conclusion If the hypothese is correct, the investigators will recommend the use of Er:YAG laser irradiation as an additional tool for disinfection of metal implants in PJIs whenever a DAIR procedure seems to be beneficial.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Er:YAG Laser intervention
In addition to the standard DAIR procedure, laser light is used to disrupt the biofilm from implant surfaced.
Er:YAG Laser irradiation
The presented DALIR procedure differs in so far from a standard treatment that after exposure all accessible metal implant surfaces and the adjacent soft tissue is irradiated manually with the Er:YAG laser all over line-by-line with an intended overlap of approximately 10% at constant spot diameter.
Interventions
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Er:YAG Laser irradiation
The presented DALIR procedure differs in so far from a standard treatment that after exposure all accessible metal implant surfaces and the adjacent soft tissue is irradiated manually with the Er:YAG laser all over line-by-line with an intended overlap of approximately 10% at constant spot diameter.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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Paracelsus Medical University
OTHER
Medical University of Vienna
OTHER
Responsible Party
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Lukas Kriechbaumer
MD
Principal Investigators
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Lukas K Kriechbaumer, MD
Role: PRINCIPAL_INVESTIGATOR
Paracelsus Medical University
Locations
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University Clinic of Orthopedics and Trauma Surgery (Paracelus Medical University Salzburg, Austria)
Salzburg, , Austria
Countries
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References
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Kriechbaumer LK, Deininger C, Planitzer A, Mitterer M, Happak W, Nurnberger S, Marko P, Filipp S, Thalhammer G, Frenzel S, Hruby L, Korn G. Laser Disinfection Acts as Biofilm-Disrupter in Periprosthetic Joint Infection (PJI). J Orthop Res. 2025 Jul 23. doi: 10.1002/jor.70035. Online ahead of print.
Other Identifiers
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1087/2021
Identifier Type: -
Identifier Source: org_study_id
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