Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
65 participants
OBSERVATIONAL
2018-12-10
2019-09-16
Brief Summary
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The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?
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Detailed Description
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Methods: Forty-two depression patients were classified in two groups: depression with gingivitis (DG) and depression with periodontally healthy (DPH) patients. Additionally, 23 systemically and periodontally healthy (SPH) individuals were enrolled to the study. Periodontal parameters were recorded. Saliva samples were collected and salivary levels of TREM-1, PGLYRP1, IL-1β were measured using Enzyme-linked Immunosorbent Assay (ELISA) kits.
depression regardless of periodontal status.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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depression with gingivitis (DG) group
The diagnosis of depressive disorder was established using the Structured Clinical Interviews for Axis I Disorders (SCID) criteria of the Diagnostic and Statistical Manual of Mental Disorders.
the gingivitis group was determined by the criteria of pocket depth of 3 mm or less.
Periodontal clinical measurements, Saliva sampling
Clinical periodontal indices; Probing depth, Clinical attachment level, bleeding on probing, gingival index, and plaque
depression with periodontally healthy (DPH) patients
The diagnosis of depressive disorder was established using the Structured Clinical Interviews for Axis I Disorders (SCID) criteria of the Diagnostic and Statistical Manual of Mental Disorders.
Periodontal clinical measurements, Saliva sampling
Clinical periodontal indices; Probing depth, Clinical attachment level, bleeding on probing, gingival index, and plaque
systemically and periodontally healthy (SPH) individuals
This group contists of individuals who are systemically and periodontally healthy
Periodontal clinical measurements, Saliva sampling
Clinical periodontal indices; Probing depth, Clinical attachment level, bleeding on probing, gingival index, and plaque
Interventions
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Periodontal clinical measurements, Saliva sampling
Clinical periodontal indices; Probing depth, Clinical attachment level, bleeding on probing, gingival index, and plaque
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* autism spectrum disorders
* other anxiety disorders
* bipolar disorder
* mental any organic mental disorder and
* smokers, substance users
18 Years
53 Years
ALL
Yes
Sponsors
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Medipol University
OTHER
Responsible Party
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DUYGU ILHAN
Asst. Prof
Locations
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Duygu Ilhan
Istanbul, Select State, Turkey (Türkiye)
Countries
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Other Identifiers
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Depression
Identifier Type: -
Identifier Source: org_study_id
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