Campylobacter Spp. Bone and Joint Infection: a Retrospective Cohort Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-01

Study Completion Date

2024-06-30

Brief Summary

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Campylobacter bacteria, a Gram-negative bacillus commensal in the digestive tract of many animals and mainly responsible for human infections with digestive origins, has been little studied in the field of osteoarticular infections (OAI). Campylobacter spp. are, however, well described, mainly for C. fetus, and pose a dual therapeutic problem: i) a capacity for persistence due to the capacity of most strains to form biofilm; and ii) potential resistance to many antibiotics. The management of IOA caused by Campylobacter spp. is not codified, and is based on small series of cases reported in the literature.

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Detailed Description

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Conditions

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Campylobacter Infections

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Management, progression and risk factors for failure of BJI caused by Campylobacter spp.

Adult patients treated for prosthetic joint infection caused by Campylobacter spp. between 01/01/2013 and 12/31/2022

Management, progression and risk factors for failure of BJI caused by Campylobacter spp.

Intervention Type OTHER

Description of demographic data (sex, age), comorbidities (ASA and Charlson scores), orthopedic and septic history, and surgical and medical management (antibiotic therapy)

Description of the evolution and risk factors for failure of osteoarticular infections caused by Campylobacter spp.

Intervention Type OTHER

Failure of treatment: defined according to a composite criterion bringing together

* persistence of the infection under treatment, and/or
* recurrence of the infection after stopping antibiotic therapy, and/or
* need for surgical revision for septic reasons more than 5 days after initial treatment, and/or
* superinfection, and/or
* definitive explantation of the material, and/or
* decision for suppressive antibiotic therapy, and/or
* amputation, and/or
* death linked to infection

Interventions

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Management, progression and risk factors for failure of BJI caused by Campylobacter spp.

Description of demographic data (sex, age), comorbidities (ASA and Charlson scores), orthopedic and septic history, and surgical and medical management (antibiotic therapy)

Intervention Type OTHER

Description of the evolution and risk factors for failure of osteoarticular infections caused by Campylobacter spp.

Failure of treatment: defined according to a composite criterion bringing together

* persistence of the infection under treatment, and/or
* recurrence of the infection after stopping antibiotic therapy, and/or
* need for surgical revision for septic reasons more than 5 days after initial treatment, and/or
* superinfection, and/or
* definitive explantation of the material, and/or
* decision for suppressive antibiotic therapy, and/or
* amputation, and/or
* death linked to infection

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* \> 18 years
* Osteoarticular infection (whatever its type), mono or polymicrobial with Campylobacter spp., diagnosed between 01/01/2013 and 12/31/2022:
* Septic arthritis: compatible clinical signs + joint fluid sample positive in culture and/or PCR positive for Campylobacter
* Spondylodiscitis: clinical signs and MRI compatible + blood cultures and/or disco-vertebral biopsy puncture positive in culture and/or PCR positive for Campylobacter
* Osteitis/osteomyelitis: compatible clinico-radiological picture + bone sample (biopsy or intraoperative sample) positive in culture and/or positive PCR for Campylobacter
* Infection on joint prosthesis or osteosynthesis equipment: documented Campylobacter infection and meeting the definition of probable or confirmed JIBS infections
* Patient who was informed and did not object to participating in the study