The Effect of Ultrasonography-guided Fascial Plane Blocks in Breast Cancer Surgery Patients

NCT ID: NCT06419504

Last Updated: 2025-05-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

96 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-17

Study Completion Date

2025-02-28

Brief Summary

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The aim of this study was to evaluate the efficacy of serratus anterior plane (SAP) block, pectoserratus plane (PECS II) block, and erector spinae plane (ESP) block on postoperative acute pain, quality of recovery and chronic pain in breast cancer surgery patients.

Detailed Description

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Breast cancer is the most common type of cancer in women. Although surgical treatment is effective and curative, it is associated with many complications in the postoperative period. Acute pain after surgery is one of them. Approximately half of women undergoing breast surgery describe significant post-operative pain (\>5 on the Visual Analogue Scale; VAS) score that is not always effectively controlled by standard post-operative treatments. Poorly controlled postoperative pain has been associated with impaired functional recovery, delayed discharge from the post-anesthetic care unit, and prolonged hospital stay. In addition, poorly managed acute pain becomes chronic and is described as 'post-mastectomy pain syndrome'. Regional techniques can reduce acute and chronic postoperative pain. The development of ultrasonography (US)-guided regional anesthesia has led to the development of fascial plane blocks. Serratus anterior plan (SAP) block, pectoserratus plan (PECS II) block, and erector spina plan (ESP) block are frequently used for postoperative analgesia in patients undergoing breast surgery. he aim of this study was to evaluate the efficacy of serratus anterior plane (SAP) block, pectoserratus plane (PECS II) block, and erector spinae plane (ESP) block on postoperative acute pain, quality of recovery and chronic pain in breast cancer surgery patients.

Conditions

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Breast Cancer

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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SAP block group

Before the surgery, US-guided SAP block will be performed

SAP block group

Intervention Type OTHER

US-guided SAP block is performed approximately 30 minutes before the surgery in patients undergoing breast cancer surgery in a separate regional anesthesia room with standard anesthesia monitoring.

PECS II block group

Before the surgery, US-guided PECS II block will be performed

PECS II block group

Intervention Type OTHER

US-guided PECS II block is performed approximately 30 minutes before the surgery in patients undergoing breast cancer surgery in a separate regional anesthesia room with standard anesthesia monitoring.

ESP block group

Before the surgery, US-guided ESP blockwill be performed

ESP block group

Intervention Type OTHER

US-guided ESP block is performed approximately 30 minutes before the surgery in patients undergoing breast cancer surgery in a separate regional anesthesia room with standard anesthesia monitoring.

Control group

No intervention

Control group

Intervention Type OTHER

No intervention

Interventions

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SAP block group

US-guided SAP block is performed approximately 30 minutes before the surgery in patients undergoing breast cancer surgery in a separate regional anesthesia room with standard anesthesia monitoring.

Intervention Type OTHER

PECS II block group

US-guided PECS II block is performed approximately 30 minutes before the surgery in patients undergoing breast cancer surgery in a separate regional anesthesia room with standard anesthesia monitoring.

Intervention Type OTHER

ESP block group

US-guided ESP block is performed approximately 30 minutes before the surgery in patients undergoing breast cancer surgery in a separate regional anesthesia room with standard anesthesia monitoring.

Intervention Type OTHER

Control group

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* elective breast surgery (modified radical mastectomy, breast conserving surgery, simple mastectomy, axillary lymph node dissection, etc.),
* 18 to 65 years old,
* American Society of Anaesthesiology (ASA) score I-III
* body mass index (BMI) \<32 kg/m2

Exclusion Criteria

* contraindications to the block applications
* history of mental or neurological disorders
* history of chronic opioid use
* chronic alcoholism
* substance use
* treatment of chronic pain
* severe liver and kidney disease
* uncooperative patients
* patients scheduled for bilateral mastectomy
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Antalya Training and Research Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hafizenur O Atalay, M.D.

Role: PRINCIPAL_INVESTIGATOR

University of Health Sciences, Antalya Training and Researh Hospital

Arzu O Karaveli, M.D.

Role: PRINCIPAL_INVESTIGATOR

University of Health Sciences, Antalya Training and Researh Hospital

Locations

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University of Health Sciences, Antalya Training and Researh Hospital

Antalya, Muratpaşa, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Wang S, Shi J, Dai Y, Zhang J, Liu Q, Yang P, Zhu N. The effect of different nerve block strategies on the quality of post-operative recovery in breast cancer patients: A randomized controlled study. Eur J Pain. 2024 Jan;28(1):166-173. doi: 10.1002/ejp.2178. Epub 2023 Sep 1.

Reference Type BACKGROUND
PMID: 37655864 (View on PubMed)

Fujii T, Shibata Y, Akane A, Aoki W, Sekiguchi A, Takahashi K, Matsui S, Nishiwaki K. A randomised controlled trial of pectoral nerve-2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy. Anaesthesia. 2019 Dec;74(12):1558-1562. doi: 10.1111/anae.14856. Epub 2019 Sep 19.

Reference Type BACKGROUND
PMID: 31535722 (View on PubMed)

Other Identifiers

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6/11

Identifier Type: -

Identifier Source: org_study_id

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