Effect of CPAP on Respiratory Load in COPD

NCT ID: NCT06390631

Last Updated: 2024-07-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 19 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-05-01
• Study Completion Date: 2024-07-09

Brief Summary

Both intrinsic positive end expiratory pressure (PEEPi) and dynamic hyperinflation are considered as inspiratory loads which increase work of breathing in patients with COPD. The application of extrinsic positive end expiratory pressure (PEEPe) supplied by CPAP has been claimed to reduce inspiratory load based on change in esophageal pressure which could be significantly affected by change in lung volume and airflow. The investigator hypothesized that CPAP could increase respiratory load because it increases lung volume.

Detailed Description

Objective: To assess the effect of CPAP on respiratory load and lung volume in stable COPD. Methods: Patients with COPD were recruited to breath under the atmosphere pressure and different levels of CPAP (4, 6, 8 and 10 cm H2O). Diaphragm EMG, esophageal pressure (Pes) and transdiaphragmatic pressure (Pdi) were recorded using balloon esophageal electrode catheter (Yinghui, Guangzhou, China). End inspiratory lung volume (EILV) was measured directly from a pneumotachograph combined with a three way valve under the different CPAP levels. Sensation of breathing difficulty was also assessed. In an additional study, the effect of airflow on pressure was investigated by a physical mode.

Conditions

Chronic Obstructive Pulmonary Disease

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

CPAP treatment

CPAP treatment in COPD patients

Group Type: EXPERIMENTAL

Continuous Positive Airway Pressure

Intervention Type: DEVICE

Patients with COPD were recruited to breath under the atmosphere pressure and different levels of CPAP (4, 6, 8 and 10 cm H2O).

Interventions

Continuous Positive Airway Pressure

Patients with COPD were recruited to breath under the atmosphere pressure and different levels of CPAP (4, 6, 8 and 10 cm H2O).

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. Willing to participate after informed consent

2. Males and females, any race and aged 40-80 years

3. GOLD II-IV COPD (post-bronchodilator FEV1 < 80 % of the predicted normal, and a post-bronchodilator FEV1/FVC < 0.70)

Exclusion Criteria

1. Patients recovering from acute exacerbation less than 4 weeks.

2. Patients with concomitant pulmonary disease (e.g. lung fibrosis, interstitial lung disorder).

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

State Key Laboratory of Respiratory Disease

OTHER

Sponsor Role: lead

Responsible Party

Yuan-Ming Luo

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yuanming Luo, PHD

Role: PRINCIPAL_INVESTIGATOR

Guangzhou Medical University

Locations

Guangzhou Medical University

Guangzhou, Guangdong, China

Countries

China

Other Identifiers

2020 No.38

Identifier Type: -

Identifier Source: org_study_id