Comparison Between Auto CPAP and Fixed CPAP in Chinese Patients With OSA

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2004-08-31

Study Completion Date

2005-06-30

Brief Summary

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AutoCPAP would lead to better compliance than FixCPAP

Detailed Description

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A prospective, randomized crossover cohort. Study subjects consisted of patients newly diagnosed with obstructive sleep apnea (OSA) confirmed with sleep study. All are CPAP naïve.

Randomization:

Arm 1: auto CPAP sleep study then auto CPAP for 2 months Arm 2: fixed CPAP titration then fixed CPAP for 2 months

Then switch over to the other arm

Trial end after 4 months, compliance and other parameters would be compared between two arms as described in the endpoint session.

Conditions

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Obstructive Sleep Apnea

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

NONE

Interventions

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AutoCPAP

Intervention Type DEVICE

FixCPAP

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* All subjects should be CPAP naïve.
* OSA confirmed with sleep study
* Presence of daytime symptoms with excessive daytime sleepiness
* Age between 18 to 65
* RDI greater than 30
* Agreed to participate in trial with informed consent signed

Exclusion Criteria

* Patients not suitable to nasal CPAP because of facial abnormality leading to poor mask fitting.
* Patients with known COPD with type II failure
* Patients with known heart failure.
* Patients with predominant central sleep apnea.
* Patients need bilevel positive airway pressure ventilation.
* Patients refusing to participate the trial.
* Patients have difficulty to follow up regularly.
* patients with untreated or under treatment of hypothyroidism

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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To K Wang, FHKCP

Role: PRINCIPAL_INVESTIGATOR

Prince of Wales Hosptial

Locations

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North District Hospital

Hong Kong, , China

Site Status

Prince of Wales Hospital

Hong Kong, , China

Site Status

Countries

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China

References

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To KW, Chan WC, Choo KL, Lam WK, Wong KK, Hui DS. A randomized cross-over study of auto-continuous positive airway pressure versus fixed-continuous positive airway pressure in patients with obstructive sleep apnoea. Respirology. 2008 Jan;13(1):79-86. doi: 10.1111/j.1440-1843.2007.01138.x.

Reference Type DERIVED

PMID: 18197915 (View on PubMed)

Other Identifiers

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CRE-2004.258-T

Identifier Type: -

Identifier Source: org_study_id