Whole-slide Image and CT Radiomics Based Deep Learning System for Prognostication Prediction in Bladder Cancer

NCT ID: NCT06389019

Last Updated: 2025-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-01

Study Completion Date

2025-10-01

Brief Summary

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Bladder cancer (BLCA), with its diverse histopathological features and varying patient outcomes, poses significant challenges in diagnosis and prognosis. Postoperative survival stratification based on radiomics feature and whole slide image feature may be useful for treatment decisions to improve prognosis. In this research, we aim to develop a deep learning-based prognostic-stratification system for automatic prediction of overall and cancer-specific survival in patients with BLCA.

Detailed Description

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Bladder cancer can be difficult to diagnose and predict outcomes for, as the disease can vary greatly between patients. This research aims to develop a new system that uses artificial intelligence to analyze patient information, including images from surgery and scans. This system could then automatically predict a patient\'s overall survival and how likely they are to survive specifically from bladder cancer. This information could be used by doctors to make better treatment decisions for each patient.

Conditions

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Bladder Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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BLCA

patients with bladder cancer who had surgery like radical cystectomy or transurethral resection of bladder tumour (TURBT).

Deep learning system for prognostication prediction in bladder cancer

Intervention Type OTHER

develop and validate a deep learning system for prognostication prediction in bladder cancer based on CT radiomics and whole slide images.

Interventions

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Deep learning system for prognostication prediction in bladder cancer

develop and validate a deep learning system for prognostication prediction in bladder cancer based on CT radiomics and whole slide images.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients with bladder cancer who had surgery like radical cystectomy or transurethral resection of bladder tumour (TURBT)
* contrast-CT scan less than two weeks before surgery
* complete CT image data and clinical data
* complete whole slide image data

Exclusion Criteria

* patients with a postoperative diagnosis of non-urothelial carcinoma
* poor quality of CT images
* incomplete clinical and follow-up data
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mingzhao Xiao

OTHER

Sponsor Role lead

Responsible Party

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Mingzhao Xiao

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Department of Urology, The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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QuanHao He

Role: CONTACT

800-555-5555

Mingzhao Xiao, PHD

Role: CONTACT

800-555-5555

Facility Contacts

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QuanHao He, PHD

Role: primary

800-555-5555

Mingzhao Xiao, PHD

Role: backup

023-89012557

Other Identifiers

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K2024-187-01

Identifier Type: OTHER

Identifier Source: secondary_id

BLCA_CMUFH

Identifier Type: -

Identifier Source: org_study_id

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