Multi-parametric MRI in Patients of Bladder Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-01

Study Completion Date

2024-06-30

Brief Summary

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Accurate preoperative detection of muscle-invasive bladder cancer remains a clinical challenge. The investigators aimed to develop and validate a knowledge-guided causal diagnostic network for the detection of muscle-invasive bladder cancer with multiparametric magnetic resonance imaging(MRI).

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Detailed Description

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Patients who underwent bladder MRI were retrospectively collected at three centers between January 2013 and September 2023. The investigators first constructed a nnUNet to segment causal region where muscle-invasive bladder cancer may occur. Subsequently, the investigators explored a causal network based on a modified ResNet3d-18 by striking a fine balance between nnUNet awareness and a self-supervised learning (SSL) model, which steered model to emulate diagnostic acumen of expert in staging muscle-invasive bladder cancer at MRI. Model was trained in center 1, and independently tested in center 1, center 2 and center 3. Ablation test was performed among all 13 Ablation-Test models using either single or multi-parametric MRI. Benefit was tested in six radiologists using vesical imaging-reporting and data system (VI-RADS) versus network-adjusted VI-RADS.

Conditions

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Muscle-invasive Bladder Cancer Artificial Intelligence

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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muscle-invasive bladder cancer

The postoperative pathology was muscle-invasive bladder cancer

magnetic resonance imaging

Intervention Type OTHER

Patients of bladder cancer underwent multiparameter magnetic resonance imaging before surgery

non-muscle-invasive bladder cancer

The postoperative pathology was non-muscle-invasive bladder cancer

magnetic resonance imaging

Intervention Type OTHER

Patients of bladder cancer underwent multiparameter magnetic resonance imaging before surgery

Interventions

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magnetic resonance imaging

Patients of bladder cancer underwent multiparameter magnetic resonance imaging before surgery

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Urothelial carcinoma of the bladder confirmed by final histopathology ②Received a standard contrast-enhanced 3.0T mpMRI before surgery ③All tumors within patients included were resected and received pathologic examination separately