Deep Learning Radiomics Model for Predicting Post-cystectomy Outcome in Muscle Invasive Bladder Cancer

NCT ID: NCT06092450

Last Updated: 2025-05-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-01

Study Completion Date

2025-06-01

Brief Summary

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Muscle invasive bladder cancer (MIBC) has a poor prognosis even after radical cystectomy. Postoperative survival stratification based on radiomics and deep learning may be useful for treatment decisions to improve prognosis. This study was aimed to develop and validate a deep learning radiomics model based on preoperative enhanced CT to predict postoperative survival in MIBC.

Detailed Description

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Conditions

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Bladder Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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MIBC

patients with pathologically confirmed MIBC after radical cystectomy

develop and validate a deep learning radiomics model based on preoperative enhanced CT image

Intervention Type OTHER

develop and validate a deep learning radiomics model based on preoperative enhanced CT to predict postoperative survival in MIBC

Interventions

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develop and validate a deep learning radiomics model based on preoperative enhanced CT image

develop and validate a deep learning radiomics model based on preoperative enhanced CT to predict postoperative survival in MIBC

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients with pathologically confirmed MIBC after radical cystectomy;
* contrast-CT scan less than two weeks before surgery;
* complete CT image data and clinical data.

Exclusion Criteria

* patients who received neoadjuvant therapy;
* non-urothelial carcinoma;
* poor quality of CT images;
* incomplete clinical and follow-up data.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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First Affiliated Hospital of Chongqing Medical University

OTHER

Sponsor Role lead

Responsible Party

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Mingzhao Xiao

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Urology, The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Zongjie Wei

Role: CONTACT

023-89012557

Facility Contacts

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Zongjie Wei

Role: primary

023-89012557

References

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Wei Z, Xv Y, Liu H, Li Y, Yin S, Xie Y, Chen Y, Lv F, Jiang Q, Li F, Xiao M. A CT-based deep learning model predicts overall survival in patients with muscle invasive bladder cancer after radical cystectomy: a multicenter retrospective cohort study. Int J Surg. 2024 May 1;110(5):2922-2932. doi: 10.1097/JS9.0000000000001194.

Reference Type DERIVED
PMID: 38349205 (View on PubMed)

Other Identifiers

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2022-K508

Identifier Type: OTHER

Identifier Source: secondary_id

AI-BLCA

Identifier Type: -

Identifier Source: org_study_id

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