Lubinus SPII Hip Stem Target Trial Emulation (LARGE)

NCT ID: NCT06367829

Last Updated: 2025-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

110000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-08

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The research questions this study aims to answer are as follows:

Primary research question:

"Do primary total hip arthroplasties for patients with OA, hip fracture or osteonecrosis with the 150mm Lubinus SPII hip stem have better mortality and stem revision rates than primary total hip arthroplasties with the 130mm hip stem?"

Secondary aims include:

* How does line-to-line cementation, compare to undersized cementation in primary total hip arthroplasty for patients with OA, hip fracture, or osteonecrosis when comparing equal size Lubinus SPII hip stems implanted with different cementation techniques?
* Does the Lubinus SPII 150mm hip stem perform equal to the Lubinus SPII 130mm hip stem in primary total hip arthroplasties for patients with OA, hip fracture or osteonecrosis when comparing patient reported outcome measures?

To answer these questions, this study has been allowed use of registered data from the LROI (dutch arthroplasty registry) and the SAR (swedish arthroplasty registry). After exclusion of patients who did not meet inclusion criteria between 2007-2020, approximately 110000 patients remain eligible for analysis.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Treatment Outcome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Primary hip replacement patients

Patients who have received primary hip replacement therapy with an indication of osteoarhritis, osteonecrosis or fracture.

Lubinus SPII hip stem 130mm

Intervention Type PROCEDURE

Shorter length of the SPII hip stem

Lubinus SPII hip stem 150mm

Intervention Type PROCEDURE

Longer length of the SPII hip stem

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Lubinus SPII hip stem 130mm

Shorter length of the SPII hip stem

Intervention Type PROCEDURE

Lubinus SPII hip stem 150mm

Longer length of the SPII hip stem

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

130mm stem 150mm stem

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Listed in registry for primary hip arthroplasty.

* Listed in registry with an indication of osteoarthritis, osteonecrosis or hip fracture.
* Received the Lubinus SPII hip stem, 130mm or 150mm, for their primary hip arthro- plasty.
* End point listed in registry (Alive, Deceased or revision).

Exclusion Criteria

* Patients who received the Lubinus SPII 150 XL conus stem.
Minimum Eligible Age

5 Years

Maximum Eligible Age

105 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

OLVG

NETWORK

Sponsor Role collaborator

Uppsala University

OTHER

Sponsor Role collaborator

Göteborg University

OTHER

Sponsor Role collaborator

Leiden University Medical Center

OTHER

Sponsor Role collaborator

JointResearch

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Rudolf Poolman, Prof. Dr.

Role: STUDY_CHAIR

OLVG

Ariena Rasker, MSc

Role: PRINCIPAL_INVESTIGATOR

Joint research OLVG

Tijs de Koningh

Role: PRINCIPAL_INVESTIGATOR

Joint research OLVG

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

OLVG

Amsterdam, North Holland, Netherlands

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Netherlands

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

WO.24.025

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Exception Cementless Hip Stem
NCT04349046 ACTIVE_NOT_RECRUITING