Genetic Feature of Congenital Hearing Loss in Chinese Population

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-23

Study Completion Date

2026-11-23

Brief Summary

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Congenital hearing loss, as well as hearing loss present at birth, is one of the most common chronic conditions in children, with a prevalence of permanent bilateral hearing loss of 2.83 per 1000 children of primary school age, which is mainly caused by genetic factors. The goal of this observational study is to learn about novel causative genes in infants with hearing loss in the Chinese population. The main problem it aims to deal with are:

* to present the genetic characteristics of the infant with hearing loss in the Chinese population
* to build up a prognostic model base on diverse data.

Participants will be asked to receive audiological tests and collection of the peripheral blood sample.

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Detailed Description

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Conditions

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Congenital Hearing Loss Congenital Deafness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Neonate with hearing loss

Neonates who failed in the neonatal hearing screening programs, including oto-acoustic emissions and automated auditory brain stem response.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age up to 6 months
* Fail in the neonatal hearing screening programs, including oto-acoustic emissions and automated auditory brain stem response
* Promise to complete the tests required at baseline and follow-ups by the legal representative
* Informed consent by the legal representative

Exclusion Criteria

* Congenital infections related to acquired or congenital hearing loss, including rubella virus, cytomegalovirus, herpes simplex virus, rubella virus, toxoplasma gondii and treponema pallidum infections
* Other explicit otologic conditions which could induce hearing loss, including cerumen, otitis media, congenital middle ear abnormalities, microtia and external ear abnormalities
* A drug with ototoxicity usage during pregnancy
* Other severe congenital anomalies

Maximum Eligible Age

6 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No