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Expanding Rapid Ascertainment Network of Schizophrenia Families in Taiwan

NCT ID: NCT01249079

Last Updated: 2010-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-10-31

Brief Summary

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This proposal responds to Request for Applications RFA-MH-08-131, which seeks applications that propose to enrich pre-existing resources for schizophrenia in the National Institute of Mental Health (NIMH) Human Genetics Initiative and to apply genomic methods to further the investigators understanding of the molecular etiology of the disorder. The overarching aims of this proposal are to quickly and cost-effectively ascertain a large sample of trio families affected by schizophrenia, and to discover causal variants for the disorder in the first family-based genome-wide association study (GWAS) of the disorder. In Taiwan, there is no such kind of policy to support this kind of GWAS study as it is a very expensive study, including collecting large family samples and genome-wide single-nucleotide polymorphism (SNP) scanning. The investigators, thus, collaborate with Professor Ming T, Tsuang and his entended subcontracted researchers to apply for this project. The investigators, the research team in Taiwan, will collect 3800 trio families (11400 subjects) of schizophrenia. Through additional ascertainment within this framework, the investigators will collect an aggregate sample with adequate power for detecting in a GWAS those variants that make even small contributions to the risk for the disorder.

The investigators will meet the overarching goals of this project by accomplishing several Specific Aims, as follows: 1) Rapidly ascertain schizophrenia trio families from Taiwanese clinical ascertainment sites; 2) Supplement NIMH Genetics Initiative collections by sending all clinical data and biomaterials to the appropriate repositories; 3) Assess the association of schizophrenia with a genome-wide panel of single-nucleotide polymorphisms (SNPs) and their constituent haplotypes; 4) Analyze quantitative schizophrenia phenotypes such as age at onset ; 5) Perform a genome-wide survey for copy-number variations related to schizophrenia; 6) Test for gene-gene interactions (epistasis); and 7) Test for gene-environment interactions, such as the well-established effect of season of birth.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Observational Model Type

FAMILY_BASED

Study Groups

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Schizophrenia Family

No intervention would be provided in this research

Intervention Type OTHER

No intervention would be provided in this research,but need to draw blood

Interventions

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No intervention would be provided in this research

No intervention would be provided in this research,but need to draw blood

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis of schizophrenia and their parents, and parents are still alive

Exclusion Criteria

* person with Mental Retardation
* persons with epilepsy
* alcohol or substance abuse combined
* in combination with other organic brain damage syndrome
Minimum Eligible Age

16 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role collaborator

China Medical University Hospital

OTHER

Sponsor Role lead

Responsible Party

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China Medical University Hospital

Principal Investigators

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Hsien-Yuan Lane

Role: STUDY_DIRECTOR

China Medical University Hospital

Locations

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China Medical University Hospital

Taichung, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Hai-Gwo Hwu

Role: CONTACT

Phone: 886-2-23122453

Email: [email protected]

Facility Contacts

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Hsien-Yuan Lane

Role: primary

Other Identifiers

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DMR99-IRB-214

Identifier Type: -

Identifier Source: org_study_id