Relationship Between Central Sensitization and Kinesiophobia in Knee Osteoarthritis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-01

Study Completion Date

2023-12-01

Brief Summary

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Objective: The knee joint is one of most common locations in OA. In recent years, it has been accepted that there are different pain phenotypes and patient subgroups in knee OA and that central sensitization (CS) mechanisms are at the forefront in some patients. It is also known that fear of movement, known as kinesiophobia, develops in patients with chronic pain. The aim of this study is to investigate CS and kinesiophobia in patients with knee OA, their relationships with each other, and their effects on pain intensity, functional status, pain catastrophizing and depression.

Materials and Methods: Forty-two patients with knee OA and 42 healthy subjects participated in our study. Demographic data, body mass index, habits, comorbidities, medications of participants and disease duration and radiographic grade of knee OA patients were recorded. VAS was used to assess the severity of pain and WOMAC was used to assess pain and functional status in patients with OA. Algometer (pressure pain threshold measurement) and Central Sensitization Inventory were used to evaluate central sensitization in all participants. Pressure pain threshold (PPT) was measured at 3 different points: knee joint, cruris and forearm. The presence of kinesiophobia was assessed with the Tampa Scale af Kinesiophobia (TSK). Pain Catastrophizing Scale (PCS) and Beck Depression Inventory (BDI) were used to assess chronic pain related symptoms.

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Detailed Description

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Forty-two patients with knee OA and 42 healthy subjects participated in our study. Demographic data, body mass index, habits, comorbidities, medications of participants and disease duration and radiographic grade of knee OA patients were recorded. VAS was used to assess the severity of pain and WOMAC was used to assess pain and functional status in patients with OA. Algometer (pressure pain threshold measurement) and Central Sensitization Inventory were used to evaluate central sensitization in all participants. Pressure pain threshold (PPT) was measured at 3 different points: knee joint, cruris and forearm. The presence of kinesiophobia was assessed with the Tampa Scale af Kinesiophobia (TSK). Pain Catastrophizing Scale (PCS) and Beck Depression Inventory (BDI) were used to assess chronic pain related symptoms.

Conditions

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Knee Osteoarthritis Central Sensitisation Kinesiophobia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Knee Osteoarthritis

Patients who have knee pain at least 6 months, 45-75 years old, kellgren-lawrence grade 1-3

Pressure Algometer

Intervention Type DIAGNOSTIC_TEST

Pressure algometer is used to detect pain pressure treshold.

Control

Subjects who have not knee pain, 45-75 years old

Pressure Algometer

Intervention Type DIAGNOSTIC_TEST

Pressure algometer is used to detect pain pressure treshold.

Interventions

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Pressure Algometer

Pressure algometer is used to detect pain pressure treshold.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Being a healthy volunteer between the ages of 45-75
* Being diagnosed with knee osteoarthritis according to ACR diagnostic criteria
* Knee pain for at least 6 months
* Kellgren-Lawrence 1, 2 or 3 radiologic grade of knee OA
* Body mass index below 35

Exclusion Criteria

* Presence of chronic widespread painful diseases other than osteoarthritis (fibromyalgia syndrome etc.), rheumatologic disease, peripheral neuropathy
* Presence of uncontrolled systemic disease
* Cooperation limitation or cognitive impairment
* Active arthritis in the knee joint to be evaluated
* Presence of prosthesis in the knees
* Pain in the forearm
* Body mass index of 35 and above

Minimum Eligible Age

45 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes